Terese Sara Høj Jørgensen1,2,3, Merete Osler1,3,4, Lars Henrik Ängquist2, Esther Zimmermann2, Gunhild Tidemann Christensen1,3,4, Thorkild I A Sørensen5,6. 1. Research Centre for Prevention and Health, Rigshospitalet-Glostrup, The Capital Region, Denmark. 2. Bispebjerg and Frederiksberg Hospital-The Capital Region, Institute of Preventive Medicine, Copenhagen, Denmark. 3. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. 4. Danish Aging Research Center, Denmark, Department of Public Health, University of Southern Denmark Odense, Denmark. 5. Bispebjerg and Frederiksberg Hospital-The Capital Region, Institute of Preventive Medicine, Copenhagen, Denmark. TSOE0005@regionh.dk. 6. Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. TSOE0005@regionh.dk.
Abstract
OBJECTIVE: The U-shaped association between body mass index (BMI) and mortality may depend on other traits with permanent health effects. Whether the association between BMI and mortality depends on levels of health-related traits known to be inversely associated with mortality throughout adult life such as height, intelligence, and education was investigated. METHODS: The study was based on a cohort of young men with data on weight, height, intelligence test score, and education from the Danish Conscription Database. In total, 346,500 men born 1939 to 1959 were followed until December 2013. The association between BMI and mortality was analyzed using Cox-regression models including interactions between BMI and height, intelligence, and education, respectively. RESULTS: BMI and mortality showed the U-shaped association from the start of the follow-up period, and it persisted through the subsequent 56 years. As expected, the mortality was inversely associated with height, intelligence, and education, but the U shape of the association between BMI and mortality was unaffected by the levels of these traits except at higher BMI values, where the slopes were steeper for men with higher levels of height, intelligence, and education. CONCLUSIONS: High and low BMI was associated with higher mortality throughout life regardless of the levels of height, intelligence, and education.
OBJECTIVE: The U-shaped association between body mass index (BMI) and mortality may depend on other traits with permanent health effects. Whether the association between BMI and mortality depends on levels of health-related traits known to be inversely associated with mortality throughout adult life such as height, intelligence, and education was investigated. METHODS: The study was based on a cohort of young men with data on weight, height, intelligence test score, and education from the Danish Conscription Database. In total, 346,500 men born 1939 to 1959 were followed until December 2013. The association between BMI and mortality was analyzed using Cox-regression models including interactions between BMI and height, intelligence, and education, respectively. RESULTS: BMI and mortality showed the U-shaped association from the start of the follow-up period, and it persisted through the subsequent 56 years. As expected, the mortality was inversely associated with height, intelligence, and education, but the U shape of the association between BMI and mortality was unaffected by the levels of these traits except at higher BMI values, where the slopes were steeper for men with higher levels of height, intelligence, and education. CONCLUSIONS: High and low BMI was associated with higher mortality throughout life regardless of the levels of height, intelligence, and education.
Authors: Brigid Wilson; Chin-Lin Tseng; Orysya Soroka; Leonard M Pogach; David C Aron Journal: BMC Health Serv Res Date: 2017-11-16 Impact factor: 2.655