Yi Wang1, Guanying Han2, Bin Guo3, Jianhua Huang4. 1. Graduated School of Liaoning Medical University, Jinzhou, China; School of Pharmaceutical Science, Liaoning Medical University, Jinzhou, China. 2. First Affiliated Hospital of Liaoning Medical University, Jinzhou, China. Electronic address: hgy19800223@163.com. 3. First Affiliated Hospital of Liaoning Medical University, Jinzhou, China. 4. First Affiliated Hospital of Liaoning Medical University, Jinzhou, China. Electronic address: hjhuadr@163.com.
Abstract
BACKGROUND: Hyaluronan (also known as hyaluronic acid) oligosaccharides (O-HA) can promote angiogenesis and wound healing; however, there are few reports on whether O-HA also plays a role in healing wounds of diabetic patients. METHODS: In this study, we prepared a special ointment containing a mixture of hyaluronan fragments from 2 to 10 disaccharide units and investigated its effects on healing the wounds of diabetic rats. RESULTS: We found that O-HA significantly increases proliferation, migration, and tube formation of endothelial cells under high glucose conditions, and topical administration of O-HA ointment promotes wound healing by increasing angiogenesis in the wounded area of the skin. The underlying mechanisms are that O-HA increases the phosphorylation of Src and ERK, and expression of TGF beta1, thereby increasing angiogenesis. CONCLUSIONS: This suggests that topical application of O-HA could be a useful method by which to treat diabetic wounds in clinical practice.
BACKGROUND:Hyaluronan (also known as hyaluronic acid) oligosaccharides (O-HA) can promote angiogenesis and wound healing; however, there are few reports on whether O-HA also plays a role in healing wounds of diabeticpatients. METHODS: In this study, we prepared a special ointment containing a mixture of hyaluronan fragments from 2 to 10 disaccharide units and investigated its effects on healing the wounds of diabeticrats. RESULTS: We found that O-HA significantly increases proliferation, migration, and tube formation of endothelial cells under high glucose conditions, and topical administration of O-HA ointment promotes wound healing by increasing angiogenesis in the wounded area of the skin. The underlying mechanisms are that O-HA increases the phosphorylation of Src and ERK, and expression of TGF beta1, thereby increasing angiogenesis. CONCLUSIONS: This suggests that topical application of O-HA could be a useful method by which to treat diabetic wounds in clinical practice.
Authors: Austin P Veith; Kayla Henderson; Adrianne Spencer; Andrew D Sligar; Aaron B Baker Journal: Adv Drug Deliv Rev Date: 2018-09-26 Impact factor: 15.470
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