Literature DB >> 27587410

Why So Few New Cardiovascular Drugs Translate to the Clinics.

Stephen F Vatner1.   

Abstract

Entities:  

Keywords:  academic fraud; cardiovascular physiology; pharmacology

Mesh：

Substances：

Year:  2016        PMID： 27587410      PMCID： PMC5012301          DOI： 10.1161/CIRCRESAHA.116.309512

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


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  15 in total

Review 1.  Cardiovascular control mechanisms in the conscious state.

Authors:  S F Vatner; E Braunwald
Journal:  N Engl J Med       Date:  1975-11-06       Impact factor: 91.245

2.  Correlation not causation: the relationship between personality traits and political ideologies.

Authors:  Brad Verhulst; Lindon J Eaves; Peter K Hatemi
Journal:  Am J Pol Sci       Date:  2012

3.  The hibernating myocardium.

Authors:  S H Rahimtoola
Journal:  Am Heart J       Date:  1989-01       Impact factor: 4.749

4.  Effects of calcium channel blocker on responses of blood flow, function, arrhythmias, and extent of infarction following reperfusion in conscious baboons.

Authors:  S F Vatner; T A Patrick; D R Knight; W T Manders; J T Fallon
Journal:  Circ Res       Date:  1988-01       Impact factor: 17.367

Review 5.  Myocardial apoptosis in heart disease: does the emperor have clothes?

Authors:  J Jose Corbalan; Dorothy E Vatner; Stephen F Vatner
Journal:  Basic Res Cardiol       Date:  2016-04-04       Impact factor: 17.165

6.  Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys.

Authors:  G J Hom; M J Forrest; T J Bach; E Brady; M R Candelore; M A Cascieri; D J Fletcher; M H Fisher; S A Iliff; R Mathvink; J Metzger; V Pecore; R Saperstein; T Shih; A E Weber; M Wyvratt; P Zafian; D E MacIntyre
Journal:  J Pharmacol Exp Ther       Date:  2001-04       Impact factor: 4.030

7.  Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity.

Authors:  Jens Petter Bakkehaug; Anders Benjamin Kildal; Erik Torgersen Engstad; Neoma Boardman; Torvind Næsheim; Leif Rønning; Ellen Aasum; Terje Steinar Larsen; Truls Myrmel; Ole-Jakob How
Journal:  Circ Heart Fail       Date:  2015-05-29       Impact factor: 8.790

8.  Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure.

Authors:  You-Tang Shen; Fady I Malik; Xin Zhao; Christophe Depre; Sunil K Dhar; Patricio Abarzúa; David J Morgans; Stephen F Vatner
Journal:  Circ Heart Fail       Date:  2010-05-24       Impact factor: 8.790

9.  Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning?

Authors:  Y T Shen; S F Vatner
Journal:  Circ Res       Date:  1995-03       Impact factor: 17.367

10.  Alpha-adrenergic-mediated reduction in coronary blood flow secondary to carotid chemoreceptor reflex activation in conscious dogs.

Authors:  P A Murray; M Lavallee; S F Vatner
Journal:  Circ Res       Date:  1984-01       Impact factor: 17.367
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  7 in total

Review 1.  Properties of porcine adipose-derived stem cells and their applications in preclinical models.

Authors:  Julien H Arrizabalaga; Matthias U Nollert
Journal:  Adipocyte       Date:  2017-03-30       Impact factor: 4.534

Review 2.  IGF-1 and cardiovascular disease.

Authors:  Yusuke Higashi; Sandeep Gautam; Patrick Delafontaine; Sergiy Sukhanov
Journal:  Growth Horm IGF Res       Date:  2019-01-31       Impact factor: 2.372

3.  18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.

Authors:  Kai-Uwe Jarr; Jianqin Ye; Yoko Kojima; Vivek Nanda; Alyssa M Flores; Pavlos Tsantilas; Ying Wang; Niloufar Hosseini-Nassab; Anne V Eberhard; Mozhgan Lotfi; Max Käller; Bryan R Smith; Lars Maegdefessel; Nicholas J Leeper
Journal:  Arterioscler Thromb Vasc Biol       Date:  2020-10-22       Impact factor: 8.311

Review 4.  Biomimetic and immunomodulatory therapeutics as an alternative to natural exosomes for vascular and cardiac applications.

Authors:  Ramiro A Villarreal-Leal; John P Cooke; Bruna Corradetti
Journal:  Nanomedicine       Date:  2021-03-24       Impact factor: 6.096

5.  Conventional and Specific-Pathogen Free Rats Respond Differently to Anesthesia and Surgical Trauma.

Authors:  Hayley L Letson; Jodie Morris; Erik Biros; Geoffrey P Dobson
Journal:  Sci Rep       Date:  2019-06-28       Impact factor: 4.379

6.  In vitro long-term repeated exposure and exposure switching of a novel tobacco vapor product in a human organotypic culture of bronchial epithelial cells.

Authors:  Shigeaki Ito; Kazushi Matsumura; Kanae Ishimori; Shinkichi Ishikawa
Journal:  J Appl Toxicol       Date:  2020-04-22       Impact factor: 3.446

7.  Why animal model studies are lost in translation.

Authors:  Nikolaos G Frangogiannis
Journal:  J Cardiovasc Aging       Date:  2022-03-31
  7 in total

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