Pedro Magalhães1, Harald Mischak, Petra Zürbig. 1. aMosaiques Diagnostics GmbH bHannover Medical School, Hannover, Germany cInstitute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
Abstract
PURPOSE OF REVIEW: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years. RECENT FINDINGS: Several urinary proteomics studies for the detection of various kidney diseases have indicated the potential of this approach aimed at diagnostic and prognostic assessment. Urinary protein biomarkers such as collagen fragments, serum albumin, α-1-antitrypsin, and uromodulin can help to explain the processes involved during disease progression. SUMMARY: Urinary proteomics has been used in several studies in order to identify and validate biomarkers associated with different kidney diseases. These biomarkers, with improved sensitivity and specificity when compared with the current gold standards, provide a significant alternative for diagnosis and prognosis, as well as improving clinical decision-making.
PURPOSE OF REVIEW: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years. RECENT FINDINGS: Several urinary proteomics studies for the detection of various kidney diseases have indicated the potential of this approach aimed at diagnostic and prognostic assessment. Urinary protein biomarkers such as collagen fragments, serum albumin, α-1-antitrypsin, and uromodulin can help to explain the processes involved during disease progression. SUMMARY: Urinary proteomics has been used in several studies in order to identify and validate biomarkers associated with different kidney diseases. These biomarkers, with improved sensitivity and specificity when compared with the current gold standards, provide a significant alternative for diagnosis and prognosis, as well as improving clinical decision-making.
Authors: Eva M Weissinger; Stefan Wittke; Thorsten Kaiser; Hermann Haller; Sebastian Bartel; Ronald Krebs; Igor Golovko; Harald D Rupprecht; Marion Haubitz; Hartmut Hecker; Harald Mischak; Danilo Fliser Journal: Kidney Int Date: 2004-06 Impact factor: 10.612
Authors: Harald Mischak; Günter Allmaier; Rolf Apweiler; Teresa Attwood; Marc Baumann; Ariela Benigni; Samuel E Bennett; Rainer Bischoff; Erik Bongcam-Rudloff; Giovambattista Capasso; Joshua J Coon; Patrick D'Haese; Anna F Dominiczak; Mohammed Dakna; Hassan Dihazi; Jochen H Ehrich; Patricia Fernandez-Llama; Danilo Fliser; Jorgen Frokiaer; Jerome Garin; Mark Girolami; William S Hancock; Marion Haubitz; Denis Hochstrasser; Rury R Holman; John P A Ioannidis; Joachim Jankowski; Bruce A Julian; Jon B Klein; Walter Kolch; Theo Luider; Ziad Massy; William B Mattes; Franck Molina; Bernard Monsarrat; Jan Novak; Karlheinz Peter; Peter Rossing; Marta Sánchez-Carbayo; Joost P Schanstra; O John Semmes; Goce Spasovski; Dan Theodorescu; Visith Thongboonkerd; Raymond Vanholder; Timothy D Veenstra; Eva Weissinger; Tadashi Yamamoto; Antonia Vlahou Journal: Sci Transl Med Date: 2010-08-25 Impact factor: 17.956
Authors: Jens Drube; Eric Schiffer; Esther Lau; Claus Petersen; Martin Kirschstein; Markus J Kemper; Ralf Lichtinghagen; Benno Ure; Harald Mischak; Lars Pape; Jochen H H Ehrich Journal: Pediatrics Date: 2012-01-23 Impact factor: 7.124
Authors: Andrew S Levey; Kai-Uwe Eckardt; Yusuke Tsukamoto; Adeera Levin; Josef Coresh; Jerome Rossert; Dick De Zeeuw; Thomas H Hostetter; Norbert Lameire; Garabed Eknoyan Journal: Kidney Int Date: 2005-06 Impact factor: 10.612
Authors: Kasper Rossing; Harald Mischak; Mohammed Dakna; Petra Zürbig; Jan Novak; Bruce A Julian; David M Good; Joshua J Coon; Lise Tarnow; Peter Rossing Journal: J Am Soc Nephrol Date: 2008-04-30 Impact factor: 10.121
Authors: Stephane Decramer; Stefan Wittke; Harald Mischak; Petra Zürbig; Michael Walden; François Bouissou; Jean-Loup Bascands; Joost P Schanstra Journal: Nat Med Date: 2006-03-19 Impact factor: 53.440
Authors: S S Roscioni; D de Zeeuw; M E Hellemons; H Mischak; P Zürbig; S J L Bakker; R T Gansevoort; H Reinhard; F Persson; M Lajer; P Rossing; H J Lambers Heerspink Journal: Diabetologia Date: 2012-10-20 Impact factor: 10.122
Authors: Martin Pejchinovski; Justyna Siwy; Jochen Metzger; Mohammed Dakna; Harald Mischak; Julie Klein; Vera Jankowski; Kyongtae T Bae; Arlene B Chapman; Andreas D Kistler Journal: Nephrol Dial Transplant Date: 2017-03-01 Impact factor: 5.992
Authors: Petra Zürbig; George Jerums; Peter Hovind; Richard J Macisaac; Harald Mischak; Stine E Nielsen; Sianna Panagiotopoulos; Frederik Persson; Peter Rossing Journal: Diabetes Date: 2012-08-07 Impact factor: 9.461
Authors: Tue Bjerg Bennike; Kate Templeton; Kimino Fujimura; Melena D Bellin; Saima Ahmed; Christoph N Schlaffner; Rohit Arora; Zobeida Cruz-Monserrate; Ramy Arnaout; Gregory J Beilman; Amit S Grover; Darwin L Conwell; Hanno Steen Journal: Pancreas Date: 2022-07-27 Impact factor: 3.243