| Literature DB >> 27584856 |
Gui-Guang Cheng1,2,3, Dan Li1,3, Bo Hou1,3, Xiao-Nian Li1,3, Lu Liu1,3, Ying-Ying Chen1,3, Paul-Keilah Lunga1,3, Afsar Khan1,3,4, Ya-Ping Liu1,3, Zhi-Li Zuo1,3, Xiao-Dong Luo1,3.
Abstract
The new melokhanines A-J (1-10) and 22 known (11-32) alkaloids were isolated from the twigs and leaves of Melodinus khasianus. The new compounds and their absolute configurations were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Melokhanine A (1), composed of a hydroxyindolinone linked to an octahydrofuro[2,3-b]pyridine moiety, is an unprecedented monoterpenoid indole alkaloid. Melokhanines B-H (2-8) possess a new 6/5/5/6/6 pentacyclic indole alkaloid skeleton. Alkaloids 1-16, 25-27, 31, and 32 showed the best antibacterial activity against Pseudomonas aeruginosa (MIC range 2-22 μM). Among the seven dermatophytes tested, compound 1 showed significant inhibitory activity against Microsporum canis, M. ferrugineum, and Trichophyton ajelloi (MIC range 38-150 μM), i.e., half the efficacy of the positive control, griseofulvin.Entities:
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Year: 2016 PMID： 27584856 DOI： 10.1021/acs.jnatprod.6b00011
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050