| Literature DB >> 27584734 |
Xuesong Wu1, Zhiwei Chen1, Yu-Bin Bai1,2, Vy M Dong1.
Abstract
We present a diastereodivergent strategy for constructing bicyclic γ-lactones bearing quaternary carbon centers via ketone hydroacylation. By applying a Rh catalyst and JoSPOphos ligand, either the anti or syn bicyclic γ-lactones can be accessed with high enantio- and diastereoselectivities, depending on the choice of solvent, temperature, and counterion.Entities:
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Year: 2016 PMID： 27584734 DOI： 10.1021/jacs.6b06227
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419