| Literature DB >> 2758404 |
R Aledo1, A Aurias, M F Avril, B Dutrillaux.
Abstract
Cytogenetic studies of a skin squamous cell carcinoma from a xeroderma pigmentosum patient were performed at several passages. They show the existence of recurrent rearrangements: 53% were dicentrics, of which 67% were of the telomere-telomere type. The telomeric region of the long arm of chromosome 12 was the most involved (in 38% of dicentrics), followed by 22p. The origin of this type of jumping rearrangement and its possible role on cell proliferation are discussed.Entities:
Mesh：
Year: 1989 PMID： 2758404 DOI： 10.1016/0165-4608(89)90150-7
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608