BACKGROUND: Video capsule endoscopy (VCE) and magnetic resonance enterography (MRE) are the prime modalities for the evaluation of small bowel (SB) Crohn's disease (CD). Mucosal inflammation on VCE is quantified using the Lewis score (LS). Diffusion-weighted (DW) magnetic resonance imaging (MRI) allows for accurate assessment of SB inflammation without administration of intravenous contrast material. The Magnetic Resonance Index of Activity (MaRiA) and the Clermont index are quantitative activity indices validated for contrast-enhanced MRE and DW-MRE, respectively. The aim of this study was to compare the quantification of distal SB inflammation by VCE and MR-related activity indices. METHODS: Patients with known quiescent SB CD were prospectively recruited and underwent MRE and VCE. LS, MaRIA and Clermont scores were calculated for the distal SB. RESULTS: Both MRI-based indices significantly correlated with the LS and the Clermont index (r = 0.50, p = 0.001 and r = 0.53, p = 0.001, respectively). Both MaRIA and Clermont scores were significantly lower in patients with mucosal healing (LS < 135). The area under the curve (AUC) with both MR scores was moderate for prediction of any mucosal inflammation (LS ⩾ 135) and excellent for prediction of moderate-to-severe inflammation (LS ⩾ 790) (0.71 and 0.74 versus 0.93 and 0.91 for MaRIA and Clermont score, respectively). CONCLUSIONS: Modest correlation between VCE- and MRE-based quantitative indices of inflammation in patients with quiescent SB CD was observed. Between-modality correlation was higher in patients with endoscopically severe disease. DW-MRE gauged by Clermont score was at least as accurate as contrast-enhanced MRE for quantification of SB inflammation.
BACKGROUND: Video capsule endoscopy (VCE) and magnetic resonance enterography (MRE) are the prime modalities for the evaluation of small bowel (SB) Crohn's disease (CD). Mucosal inflammation on VCE is quantified using the Lewis score (LS). Diffusion-weighted (DW) magnetic resonance imaging (MRI) allows for accurate assessment of SB inflammation without administration of intravenous contrast material. The Magnetic Resonance Index of Activity (MaRiA) and the Clermont index are quantitative activity indices validated for contrast-enhanced MRE and DW-MRE, respectively. The aim of this study was to compare the quantification of distal SB inflammation by VCE and MR-related activity indices. METHODS:Patients with known quiescent SB CD were prospectively recruited and underwent MRE and VCE. LS, MaRIA and Clermont scores were calculated for the distal SB. RESULTS: Both MRI-based indices significantly correlated with the LS and the Clermont index (r = 0.50, p = 0.001 and r = 0.53, p = 0.001, respectively). Both MaRIA and Clermont scores were significantly lower in patients with mucosal healing (LS < 135). The area under the curve (AUC) with both MR scores was moderate for prediction of any mucosal inflammation (LS ⩾ 135) and excellent for prediction of moderate-to-severe inflammation (LS ⩾ 790) (0.71 and 0.74 versus 0.93 and 0.91 for MaRIA and Clermont score, respectively). CONCLUSIONS: Modest correlation between VCE- and MRE-based quantitative indices of inflammation in patients with quiescent SB CD was observed. Between-modality correlation was higher in patients with endoscopically severe disease. DW-MRE gauged by Clermont score was at least as accurate as contrast-enhanced MRE for quantification of SB inflammation.
Entities:
Keywords:
Crohn’s disease; diffusion-weighted MRI; magnetic resonance enterography; videocapsule endoscopy
Authors: D Laharie; S Mesli; F El Hajbi; E Chabrun; E Chanteloup; M Capdepont; S Razaire; V de Lédinghen; F Zerbib Journal: Aliment Pharmacol Ther Date: 2011-06-14 Impact factor: 8.171
Authors: Geert D'Haens; Mark Löwenberg; Mark A Samaan; Denis Franchimont; Cyriel Ponsioen; Gijs R van den Brink; Paul Fockens; Peter Bossuyt; Leila Amininejad; Gopalan Rajamannar; Elsemieke M Lensink; Andre M Van Gossum Journal: Clin Gastroenterol Hepatol Date: 2015-03-21 Impact factor: 11.382
Authors: José Cotter; Francisca Dias de Castro; Joana Magalhães; Maria João Moreira; Bruno Rosa Journal: Endoscopy Date: 2014-11-20 Impact factor: 10.093
Authors: J Rimola; S Rodriguez; O García-Bosch; I Ordás; E Ayala; M Aceituno; M Pellisé; C Ayuso; E Ricart; L Donoso; J Panés Journal: Gut Date: 2009-01-09 Impact factor: 23.059
Authors: Fabian Schnitzler; Herma Fidder; Marc Ferrante; Maja Noman; Ingrid Arijs; Gert Van Assche; Ilse Hoffman; Kristel Van Steen; Séverine Vermeire; Paul Rutgeerts Journal: Inflamm Bowel Dis Date: 2009-09 Impact factor: 5.325
Authors: C Hordonneau; A Buisson; J Scanzi; F Goutorbe; B Pereira; C Borderon; D Da Ines; P F Montoriol; J M Garcier; L Boyer; G Bommelaer; V Petitcolin Journal: Am J Gastroenterol Date: 2013-11-19 Impact factor: 10.864
Authors: Stuart A Taylor; Susan Mallett; Gauraang Bhatnagar; Rachel Baldwin-Cleland; Stuart Bloom; Arun Gupta; Peter J Hamlin; Ailsa L Hart; Antony Higginson; Ilan Jacobs; Sara McCartney; Anne Miles; Charles D Murray; Andrew A Plumb; Richard C Pollok; Shonit Punwani; Laura Quinn; Manuel Rodriguez-Justo; Zainib Shabir; Andrew Slater; Damian Tolan; Simon Travis; Alastair Windsor; Peter Wylie; Ian Zealley; Steve Halligan Journal: Lancet Gastroenterol Hepatol Date: 2018-06-18
Authors: Nadia Mazen Hijaz; Thomas Mario Attard; Jennifer Marie Colombo; Neil Joseph Mardis; Craig Alan Friesen Journal: World J Gastroenterol Date: 2019-07-28 Impact factor: 5.742