Literature DB >> 27582857

Financial implications and maternal impact of national recommendations for thromboprophylaxis: a retrospective cross-sectional analysis.

Cressida Bond1, Kate O'Brien1, Tim Draycott1, Robert Fox1.   

Abstract

BACKGROUND: Thromboembolism was a leading direct cause of maternal death in the UK in the last Saving Mothers' Lives report. National guidance proposes that all women should be risk assessed in pregnancy and after delivery.
METHODS: An audit was designed to assess the financial implication for our service. One hundred consecutive live and stillbirths were identified using the maternity database; 97 case records were obtained. Risk factors were identified and individual scores were calculated, together with the proportion that would have extended measures (low-molecular-weight heparin [LMWH], antiembolic stockings).
RESULTS: The series appeared to be representative of the UK pregnant population in terms of age, parity, body mass index, smoking and caesarean rate. Antenatally, 2.1% had a Royal College of Obstetricians and Gynaecologists (RCOG) risk score of three or more and would have been advised to have LMWH throughout pregnancy and the puerperium. Postnatally, 40.1% had an RCOG score of two or more and would have required enoxaparin for one to six weeks. The annual cost of stockings, LMWH and sharps bins approximate to GB£44,847 for every one thousand deliveries, GB£2.6 million for each life saved. About 10% of normal-weight postnatal women who achieved a vaginal birth had a risk score prompting thromboprophylaxis for at least seven days.
CONCLUSIONS: These data suggest that the current guidance might represent overmedicalization of pregnancy and that the criteria for thromboprophylaxis should be refined further.

Entities:  

Keywords:  maternal death; prophylaxis; venous thromboembolism

Year:  2011        PMID: 27582857      PMCID: PMC4989743          DOI: 10.1258/om.2011.110082

Source DB:  PubMed          Journal:  Obstet Med        ISSN: 1753-495X


  6 in total

1.  Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital: summary of the NICE guideline.

Authors:  Jennifer Hill; Tom Treasure
Journal:  Heart       Date:  2010-06       Impact factor: 5.994

Review 2.  Preventing venous thromboembolism in medical patients.

Authors:  Alain Leizorovicz; Patrick Mismetti
Journal:  Circulation       Date:  2004-12-14       Impact factor: 29.690

3.  Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study.

Authors:  John A Heit; Catie E Kobbervig; Andra H James; Tanya M Petterson; Kent R Bailey; L Joseph Melton
Journal:  Ann Intern Med       Date:  2005-11-15       Impact factor: 25.391

4.  Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36,821 women over a 15-year period.

Authors:  N Heslehurst; L J Ells; H Simpson; A Batterham; J Wilkinson; C D Summerbell
Journal:  BJOG       Date:  2007-02       Impact factor: 6.531

5.  Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom.

Authors:  Roch Cantwell; Thomas Clutton-Brock; Griselda Cooper; Andrew Dawson; James Drife; Debbie Garrod; Ann Harper; Diana Hulbert; Sebastian Lucas; John McClure; Harry Millward-Sadler; James Neilson; Catherine Nelson-Piercy; Jane Norman; Colm O'Herlihy; Margaret Oates; Judy Shakespeare; Michael de Swiet; Catherine Williamson; Valerie Beale; Marian Knight; Christopher Lennox; Alison Miller; Dharmishta Parmar; Jane Rogers; Anna Springett
Journal:  BJOG       Date:  2011-03       Impact factor: 6.531

6.  Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study.

Authors:  E R Pomp; A M Lenselink; F R Rosendaal; C J M Doggen
Journal:  J Thromb Haemost       Date:  2008-01-31       Impact factor: 5.824

  6 in total
  1 in total

1.  Maternal deaths: the good, the bad and the ugly.

Authors:  Catherine Nelson-Piercy; Sandra Lowe; Karen Rosene-Montella
Journal:  Obstet Med       Date:  2011-06-09
  1 in total

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