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Literature DB >> 27582671

Putting the Horse Before the Cart: Looking to Presynaptic Mechanisms in Genetic Models.

Matthew Weston.

Abstract

Entities: Species

Year: 2016 PMID： 27582671 PMCID： PMC4988070 DOI： 10.5698/1535-7511-16.4.266

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

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7 in total

1. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features.

Authors: Sergey Kalachikov; Oleg Evgrafov; Barbara Ross; Melodie Winawer; Christie Barker-Cummings; Filippo Martinelli Boneschi; Chang Choi; Pavel Morozov; Kamna Das; Elita Teplitskaya; Andrew Yu; Eftihia Cayanis; Graciela Penchaszadeh; Andreas H Kottmann; Timothy A Pedley; W Allen Hauser; Ruth Ottman; T Conrad Gilliam
Journal: Nat Genet Date: 2002-01-28 Impact factor: 38.330

2. The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

Authors: Uwe Schulte; Jörg-Oliver Thumfart; Nikolaj Klöcker; Claudia A Sailer; Wolfgang Bildl; Martin Biniossek; Doris Dehn; Thomas Deller; Silke Eble; Karen Abbass; Tanja Wangler; Hans-Günther Knaus; Bernd Fakler
Journal: Neuron Date: 2006-03-02 Impact factor: 17.173

3. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.

Authors: Yuko Fukata; Hillel Adesnik; Tsuyoshi Iwanaga; David S Bredt; Roger A Nicoll; Masaki Fukata
Journal: Science Date: 2006-09-22 Impact factor: 47.728

4. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy.

Authors: José M Morante-Redolat; Ana Gorostidi-Pagola; Salomé Piquer-Sirerol; Amets Sáenz; Juan J Poza; Juan Galán; Stefan Gesk; Theologia Sarafidou; Victor-F Mautner; Simona Binelli; Eike Staub; Bernd Hinzmann; Lisa French; Jean-F Prud'homme; Daniela Passarelli; Paolo Scannapieco; Carlo A Tassinari; Giuliano Avanzini; José F Martí-Massó; Lan Kluwe; Panagiotis Deloukas; Nicholas K Moschonas; Roberto Michelucci; Reiner Siebert; Carlo Nobile; Jordi Pérez-Tur; Adolfo López de Munain
Journal: Hum Mol Genet Date: 2002-05-01 Impact factor: 6.150

Putting the Horse Before the Cart: Looking to Presynaptic Mechanisms in Genetic Models.

1. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features.

2. The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

3. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.

4. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy.

5. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability.

6. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy.

7. Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice.