Rachel Zeig-Owens1,2, Anna Nolan1,3, Barbara Putman4, Ankura Singh1,2, David J Prezant1,5, Michael D Weiden1,3. 1. The Bureau of Health Services, Fire Department of New York City, Brooklyn, New York. 2. Department of Medicine, Montefiore Medical Center, Bronx, New York. 3. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New York. 4. Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. 5. Division of Pulmonary Medicine, Montefiore Medical Center, Bronx, New York.
Abstract
BACKGROUND: High rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some continued to experience decline over 14 years of follow-up. Similarly, some with rhinosinusitis had symptoms requiring sinus surgery. AIM: To increase generalizability of biomarker investigation, we describe biomarkers of risk for upper and lower airway injury that do not require stored serum. METHODS: We review WTC biomarker literature. RESULTS: Cytokines expressed in stored serum from the first 6 months post-9/11 can identify individuals at higher risk for future abnormal pulmonary function. CONCLUSION: This research will help identify individuals at high risk of lung and sinus disease that develop after these, or future, irritant exposures for intensive monitoring and treatment. It may also identify targets for effective therapeutic interventions. Am. J. Ind. Med. 59:788-794, 2016.
BACKGROUND: High rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some continued to experience decline over 14 years of follow-up. Similarly, some with rhinosinusitis had symptoms requiring sinus surgery. AIM: To increase generalizability of biomarker investigation, we describe biomarkers of risk for upper and lower airway injury that do not require stored serum. METHODS: We review WTC biomarker literature. RESULTS: Cytokines expressed in stored serum from the first 6 months post-9/11 can identify individuals at higher risk for future abnormal pulmonary function. CONCLUSION: This research will help identify individuals at high risk of lung and sinus disease that develop after these, or future, irritant exposures for intensive monitoring and treatment. It may also identify targets for effective therapeutic interventions. Am. J. Ind. Med. 59:788-794, 2016.
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Authors: Caralee E Caplan-Shaw; Herman Yee; Linda Rogers; Jerrold L Abraham; Sam S Parsia; David P Naidich; Alain Borczuk; Andre Moreira; Maria C Shiau; Jane P Ko; Geraldine Brusca-Augello; Kenneth I Berger; Roberta M Goldring; Joan Reibman Journal: J Occup Environ Med Date: 2011-09 Impact factor: 2.162
Authors: Mayris P Webber; Michelle S Glaser; Jessica Weakley; Jackie Soo; Fen Ye; Rachel Zeig-Owens; Michael D Weiden; Anna Nolan; Thomas K Aldrich; Kerry Kelly; David Prezant Journal: Am J Ind Med Date: 2011-09 Impact factor: 2.214
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Authors: Gisela I Banauch; Mark Brantly; Gabriel Izbicki; Charles Hall; Alan Shanske; Robert Chavko; Ganesha Santhyadka; Vasilios Christodoulou; Michael D Weiden; David J Prezant Journal: Chest Date: 2010-07-15 Impact factor: 9.410
Authors: Justin K Niles; Mayris P Webber; Xiaoxue Liu; Rachel Zeig-Owens; Charles B Hall; Hillel W Cohen; Michelle S Glaser; Jessica Weakley; Theresa M Schwartz; Michael D Weiden; Anna Nolan; Thomas K Aldrich; Lara Glass; Kerry J Kelly; David J Prezant Journal: Am J Ind Med Date: 2014-06-04 Impact factor: 2.214
Authors: Matthew J Mears; David M Aslaner; Chad T Barson; Mitchell D Cohen; Matthew W Gorr; Loren E Wold Journal: Life Sci Date: 2021-11-14 Impact factor: 5.037
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