INTRODUCTION: Small airway dysfunction occurs following WTC dust exposure, but its role in producing symptoms is unclear. METHODS: Methacholine challenge (MCT) was used to assess the relationship between onset of respiratory symptoms and small airway abnormalities in 166 symptomatic WTC dust-exposed patients. Forced oscillation testing (FOT) and respiratory symptoms were assessed during MCT. FOT parameters included resistance at 5 and 20 Hz (R5 and R20 ) and the R5 minus R20 (R5-20 ). RESULTS: Baseline spirometry was normal in all (mean FEV1 100 + 13% predicted, mean FEV1 /FVC 80 + 4%). MCT revealed bronchial hyperreactivity by spirometry in 67 patients. An additional 24 patients became symptomatic despite minimal FEV1 change (<5%); symptom onset coincided with increased R5 and R5-20 (P > 0.001 vs. baseline). The dose-response of FOT (reactivity) was greater compared with subjects that remained asymptomatic (P < 0.05). CONCLUSIONS: FOT during MCT uncovered reactivity in small airways as a mechanism for respiratory symptoms in subjects with inhalational lung injury. Am. J. Ind. Med. 59:767-776, 2016.
INTRODUCTION: Small airway dysfunction occurs following WTC dust exposure, but its role in producing symptoms is unclear. METHODS:Methacholine challenge (MCT) was used to assess the relationship between onset of respiratory symptoms and small airway abnormalities in 166 symptomatic WTC dust-exposed patients. Forced oscillation testing (FOT) and respiratory symptoms were assessed during MCT. FOT parameters included resistance at 5 and 20 Hz (R5 and R20 ) and the R5 minus R20 (R5-20 ). RESULTS: Baseline spirometry was normal in all (mean FEV1 100 + 13% predicted, mean FEV1 /FVC 80 + 4%). MCT revealed bronchial hyperreactivity by spirometry in 67 patients. An additional 24 patients became symptomatic despite minimal FEV1 change (<5%); symptom onset coincided with increased R5 and R5-20 (P > 0.001 vs. baseline). The dose-response of FOT (reactivity) was greater compared with subjects that remained asymptomatic (P < 0.05). CONCLUSIONS: FOT during MCT uncovered reactivity in small airways as a mechanism for respiratory symptoms in subjects with inhalational lung injury. Am. J. Ind. Med. 59:767-776, 2016.
Authors: Abigail Gaylord; Kenneth I Berger; Mrudula Naidu; Teresa M Attina; Joseph Gilbert; Tony T Koshy; Xiaoxia Han; Michael Marmor; Yongzhao Shao; Robert Giusti; Roberta M Goldring; Kurunthachalam Kannan; Leonardo Trasande Journal: Environ Res Date: 2019-02-16 Impact factor: 6.498
Authors: Alice Trye; Kenneth I Berger; Mrudula Naidu; Teresa M Attina; Joseph Gilbert; Tony T Koshy; Xiaoxia Han; Michael Marmor; Yongzhao Shao; Robert Giusti; Roberta M Goldring; Leonardo Trasande Journal: J Pediatr Date: 2018-07-18 Impact factor: 4.406
Authors: Sophia Kwon; George Crowley; Mena Mikhail; Rachel Lam; Emily Clementi; Rachel Zeig-Owens; Theresa M Schwartz; Mengling Liu; David J Prezant; Anna Nolan Journal: Int J Environ Res Public Health Date: 2019-04-26 Impact factor: 3.390