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Literature DB >> 27582466

Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression.

Hironori Nishitsuji¹, Saneyuki Ujino², Sachiyo Yoshio², Masaya Sugiyama², Masashi Mizokami², Tatsuya Kanto², Kunitada Shimotohno².

Abstract

Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.

Entities: Disease Gene Species

Keywords: ISG; innate immunity; interferon; lncRNA

Mesh：

Substances：

Year: 2016 PMID： 27582466 PMCID： PMC5027408 DOI： 10.1073/pnas.1525022113

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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