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Literature DB >> 2758220

Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms.

S Bacman¹, E Borda, B Denduchis, L Lustig, L Sterin-Borda.

Abstract

1. Antilaminin IgG decreased the dF/dt of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non-competitive fashion. 2. Inhibitors of nicotinic and muscarinic cholinoceptors impaired the negative inotropic action of antilaminin IgG in mouse isolated atria. Hemicholinium and tetrodotoxin also reduced the response while the antihistamine, pyrilamine was without effect. 3. These results suggest that antilaminin IgG modulates cholinergic function in mouse isolated atria. Possible mechanisms are discussed.

Entities: Chemical Species

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Year: 1989 PMID： 2758220 PMCID： PMC1854520 DOI： 10.1111/j.1476-5381.1989.tb11964.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

20 in total

Review 1. Cell surface interactions with extracellular materials.

Authors: K M Yamada
Journal: Annu Rev Biochem Date: 1983 Impact factor: 23.643

2. Relationship of collagen-tailed acetylcholinesterase with basal lamina components. Absence of binding with laminin, fibronectin, and collagen types IV and V and lack of reactivity with different anti-collagen sera.

Authors: J Grassi; J Massoulié; R Timpl
Journal: Eur J Biochem Date: 1983-06-01

Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms.

Review 1. Cell surface interactions with extracellular materials.

2. Relationship of collagen-tailed acetylcholinesterase with basal lamina components. Absence of binding with laminin, fibronectin, and collagen types IV and V and lack of reactivity with different anti-collagen sera.

3. Interactions of asymmetric forms of acetylcholinesterase with basement membrane components.

4. Cholinesterase is associated with the basal lamina at the neuromuscular junction.

5. Nerve growth factor, laminin, and fibronectin promote neurite growth in human fetal sensory ganglia cultures.

6. Alloimmune IgG binds and modulates cardiac beta-adrenoceptor activity.

7. Role of beta 2-adrenoceptors in the biological effect of autoimmune orchitis spleen cells.

8. Isolation of a laminin-binding protein from muscle cell membranes.

9. Antibodies to laminin in Chagas' disease.

10. Laminin, fibronectin, and collagen in synaptic and extrasynaptic portions of muscle fiber basement membrane.

1. Participation of cytoskeleton in the effect of antilaminin IgG on cardiac cholinoceptors.