Stela Vujosevic1, Porzia Pucci1, Margerita Casciano1, Evelyn Longhin1, Enrica Convento1, Silvia Bini1, Edoardo Midena2,3. 1. Department of Ophthalmology University of Padova, Via Giustiniani 2, 35128, Padova, Italy. 2. Department of Ophthalmology University of Padova, Via Giustiniani 2, 35128, Padova, Italy. edoardo.midena@unipd.it. 3. Fondazione G. B. Bietti, IRCCS, Roma, Italy. edoardo.midena@unipd.it.
Abstract
PURPOSE: To evaluate functional changes (retinal sensitivity and fixation characteristics) determined by microperimetry in patients with early and intermediate AMD over 6 years. METHODS: Prospective, longitudinal follow-up (FU) study of 16 patients (29 eyes) with early and intermediate AMD (AREDS 2 and AREDS 3 classification). All eyes underwent: complete ophthalmic examination with best corrected visual acuity (BCVA) determination, color fundus photo (CFP), optical coherence tomography and microperimetry. All CFP were evaluated by two retinal specialists masked to functional data for changes in severity of clinical features over the course of FU. RESULTS: Of 17 eyes graded as AREDS 2 at baseline, 14 (82.35 %) remained stable, and 3 (18.75 %) progressed to AREDS 3. Of 12 eyes graded as AREDS 3 at baseline, 10 remained stable (83.33 %), and 2 (16.67 %) progressed to AREDS 4. Mean BCVA significantly deteriorated in both AREDS 2 (p = 0.006) and AREDS 3 (p = 0.016), with greater decrease in AREDS 3 (p = 0.01)6. Mean retinal sensitivity (RS) significantly decreased over time in both AREDS 2 (p < 0.0001) and AREDS 3 group (p = 0.002), with greater decrease in AREDS 3 (p = 0.006). The mean number of dense scotomas did not change in AREDS 2 (p = 0.3), but significantly increased in the AREDS 3 group (p = 0.035). Points with decreased RS were located in all but the central point (p < 0.0001 for all), without significant differences in number among rings. In the AREDS 2 group, fixation stability remained unchanged. In the AREDS 3 group, four eyes deteriorated from stable to unstable fixation at FU (p = 0.045). CONCLUSION: A significant deterioration in RS is reported in early and intermediate AMD eyes, whereas fixation stability changed only in intermediate AMD (AREDS 3) over long-term follow-up. Microperimetry examination can become a new functional biomarker in early and intermediate AMD patients.
PURPOSE: To evaluate functional changes (retinal sensitivity and fixation characteristics) determined by microperimetry in patients with early and intermediate AMD over 6 years. METHODS: Prospective, longitudinal follow-up (FU) study of 16 patients (29 eyes) with early and intermediate AMD (AREDS 2 and AREDS 3 classification). All eyes underwent: complete ophthalmic examination with best corrected visual acuity (BCVA) determination, color fundus photo (CFP), optical coherence tomography and microperimetry. All CFP were evaluated by two retinal specialists masked to functional data for changes in severity of clinical features over the course of FU. RESULTS: Of 17 eyes graded as AREDS 2 at baseline, 14 (82.35 %) remained stable, and 3 (18.75 %) progressed to AREDS 3. Of 12 eyes graded as AREDS 3 at baseline, 10 remained stable (83.33 %), and 2 (16.67 %) progressed to AREDS 4. Mean BCVA significantly deteriorated in both AREDS 2 (p = 0.006) and AREDS 3 (p = 0.016), with greater decrease in AREDS 3 (p = 0.01)6. Mean retinal sensitivity (RS) significantly decreased over time in both AREDS 2 (p < 0.0001) and AREDS 3 group (p = 0.002), with greater decrease in AREDS 3 (p = 0.006). The mean number of dense scotomas did not change in AREDS 2 (p = 0.3), but significantly increased in the AREDS 3 group (p = 0.035). Points with decreased RS were located in all but the central point (p < 0.0001 for all), without significant differences in number among rings. In the AREDS 2 group, fixation stability remained unchanged. In the AREDS 3 group, four eyes deteriorated from stable to unstable fixation at FU (p = 0.045). CONCLUSION: A significant deterioration in RS is reported in early and intermediate AMD eyes, whereas fixation stability changed only in intermediate AMD (AREDS 3) over long-term follow-up. Microperimetry examination can become a new functional biomarker in early and intermediate AMDpatients.
Authors: Kathrin I Hartmann; Dirk-Uwe G Bartsch; Lingyun Cheng; Jae S Kim; Maria L Gomez; Helaina Klein; William R Freeman Journal: Retina Date: 2011 Jul-Aug Impact factor: 4.256
Authors: Gildo Y Fujii; Eugene de Juan; Janet Sunness; Mark S Humayun; Dante J Pieramici; Tom S Chang Journal: Ophthalmology Date: 2002-09 Impact factor: 12.079
Authors: Maximilian Pfau; Moritz Lindner; Martin Gliem; Julia S Steinberg; Sarah Thiele; Robert P Finger; Monika Fleckenstein; Frank G Holz; Steffen Schmitz-Valckenberg Journal: Eye (Lond) Date: 2018-08-01 Impact factor: 3.775
Authors: S Tammy Hsu; Atalie C Thompson; Sandra S Stinnett; Ulrich F O Luhmann; Lejla Vajzovic; Anupama Horne; Stefanie G Schuman; Cynthia A Toth; Scott W Cousins; Eleonora M Lad Journal: Ophthalmol Retina Date: 2019-03-21
Authors: Etienne M Schönbach; Rupert W Strauss; Beatriz Muñoz; Yulia Wolfson; Mohamed A Ibrahim; David G Birch; Eberhart Zrenner; Janet S Sunness; Michael S Ip; SriniVas R Sadda; Sheila K West; Hendrik P N Scholl Journal: JAMA Ophthalmol Date: 2020-07-01 Impact factor: 7.389
Authors: Leon von der Emde; Maximilian Pfau; Sarah Thiele; Philipp T Möller; Ruth Hassenrik; Monika Fleckenstein; Frank G Holz; Steffen Schmitz-Valckenberg Journal: Transl Vis Sci Technol Date: 2018-01-09 Impact factor: 3.283
Authors: Leon von der Emde; Maximilian Pfau; Chantal Dysli; Sarah Thiele; Philipp T Möller; Moritz Lindner; Matthias Schmid; Monika Fleckenstein; Frank G Holz; Steffen Schmitz-Valckenberg Journal: Sci Rep Date: 2019-07-31 Impact factor: 4.379
Authors: John D Rodriguez; Keith Lane; David A Hollander; Aron Shapiro; Sunita Saigal; Andrew J Hertsenberg; Garrick Wallstrom; Divya Narayanan; Endri Angjeli; Mark B Abelson Journal: Clin Ophthalmol Date: 2018-07-27
Authors: Susanne G Pondorfer; Manuel Heinemann; Maximilian W M Wintergerst; Maximilian Pfau; Annika L Strömer; Frank G Holz; Robert P Finger Journal: PLoS One Date: 2020-04-16 Impact factor: 3.240