BACKGROUND: Although the relationship between malignancies and catecholamine-induced myocardial stunning remains largely speculative, it has been suggested that the presence of cancer may lower the threshold for stress stimuli and/or may aggravate cardiac adrenoreceptor sensitivity. We sought to investigate whether associations exist between a previous or current diagnosis of malignancy, diagnostic parameters during hospitalization and death in takotsubo. METHODS AND RESULTS: The 154 takotsubo patients were retrospectively identified between May 2008 and December 2014. Previous history of malignancy was identified in 44 patients (28.5%). Cardiac arrest was present at admission in 13 patients (8.4%). Intra-aortic balloon pump was inserted in 16 patients (10.4%). In patients with malignancy, higher B-type natriuretic peptide (BNP), leukocyte and C-reactive protein (CRP) peaks could be observed during the hospital phase. Initial impairment of left ventricular ejection fraction was negatively related to BNP, leukocyte, and CRP peaks. At a median follow-up of 364 days, all-cause death occurred in 41 patients (26.6%) and cardiac death in 12 patients (7.7%). Multivariate Cox regression analysis identified malignancy (hazard ratio 4.77 (1.02-22.17), leukocyte peak and age as independent predictors of cardiac death. Malignancy (2.62 (1.26-5.44), leukocyte peak (1.05 (1.01-1.08) and initial cardiac arrest (6.68 (2.47-18.01) were identified as independent predictors of overall mortality. CONCLUSIONS: In the present takotsubo patients, the prevalence of malignancy was high and may have affected cardiovascular outcomes through the activation of inflammatory and neurohormonal mechanisms. (Circ J 2016; 80: 2192-2198).
BACKGROUND: Although the relationship between malignancies and catecholamine-induced myocardial stunning remains largely speculative, it has been suggested that the presence of cancer may lower the threshold for stress stimuli and/or may aggravate cardiac adrenoreceptor sensitivity. We sought to investigate whether associations exist between a previous or current diagnosis of malignancy, diagnostic parameters during hospitalization and death in takotsubo. METHODS AND RESULTS: The 154 takotsubo patients were retrospectively identified between May 2008 and December 2014. Previous history of malignancy was identified in 44 patients (28.5%). Cardiac arrest was present at admission in 13 patients (8.4%). Intra-aortic balloon pump was inserted in 16 patients (10.4%). In patients with malignancy, higher B-type natriuretic peptide (BNP), leukocyte and C-reactive protein (CRP) peaks could be observed during the hospital phase. Initial impairment of left ventricular ejection fraction was negatively related to BNP, leukocyte, and CRP peaks. At a median follow-up of 364 days, all-cause death occurred in 41 patients (26.6%) and cardiac death in 12 patients (7.7%). Multivariate Cox regression analysis identified malignancy (hazard ratio 4.77 (1.02-22.17), leukocyte peak and age as independent predictors of cardiac death. Malignancy (2.62 (1.26-5.44), leukocyte peak (1.05 (1.01-1.08) and initial cardiac arrest (6.68 (2.47-18.01) were identified as independent predictors of overall mortality. CONCLUSIONS: In the present takotsubo patients, the prevalence of malignancy was high and may have affected cardiovascular outcomes through the activation of inflammatory and neurohormonal mechanisms. (Circ J 2016; 80: 2192-2198).
Authors: Mohammad Abumayyaleh; Ibrahim El-Battrawy; Marvin Kummer; Thorsten Gietzen; Michael Behnes; Xiao-Bo Zhou; Siegfried Lang; Martin Borggrefe; Ibrahim Akin Journal: In Vivo Date: 2020 Nov-Dec Impact factor: 2.155
Authors: Sören J Backhaus; Thomas Stiermaier; Torben Lange; Amedeo Chiribiri; Pablo Lamata; Johannes Uhlig; Johannes T Kowallick; Uwe Raaz; Adriana Villa; Joachim Lotz; Gerd Hasenfuß; Holger Thiele; Ingo Eitel; Andreas Schuster Journal: Int J Cardiol Date: 2018-04-22 Impact factor: 4.164
Authors: Victoria L Cammann; Annahita Sarcon; Katharina J Ding; Burkhardt Seifert; Ken Kato; Davide Di Vece; Konrad A Szawan; Sebastiano Gili; Stjepan Jurisic; Beatrice Bacchi; Jozef Micek; Antonio H Frangieh; L Christian Napp; Milosz Jaguszewski; Eduardo Bossone; Rodolfo Citro; Fabrizio D'Ascenzo; Jennifer Franke; Michel Noutsias; Maike Knorr; Susanne Heiner; Christof Burgdorf; Wolfgang Koenig; Holger Thiele; Carsten Tschöpe; Lawrence Rajan; Guido Michels; Roman Pfister; Alessandro Cuneo; Claudius Jacobshagen; Mahir Karakas; Adrian Banning; Florim Cuculi; Richard Kobza; Thomas A Fischer; Tuija Vasankari; K E Juhani Airaksinen; Rafal Dworakowski; Christoph Kaiser; Stefan Osswald; Leonarda Galiuto; Wolfgang Dichtl; Clément Delmas; Olivier Lairez; John D Horowitz; Martin Kozel; Petr Widimský; Petr Tousek; David E Winchester; Ekaterina Gilyarova; Alexandra Shilova; Mikhail Gilyarov; Ibrahim El-Battrawy; Ibrahim Akin; Christian Ukena; Johann Bauersachs; Burkert M Pieske; Gerd Hasenfuß; Wolfgang Rottbauer; Ruediger C Braun-Dullaeus; Grzegorz Opolski; Philip MacCarthy; Stephan B Felix; Martin Borggrefe; Carlo Di Mario; Filippo Crea; Hugo A Katus; Heribert Schunkert; Thomas Münzel; Michael Böhm; Jeroen J Bax; Abhiram Prasad; Jerold Shinbane; Thomas F Lüscher; Frank Ruschitzka; Jelena R Ghadri; Christian Templin Journal: J Am Heart Assoc Date: 2019-07-17 Impact factor: 5.501