| Literature DB >> 27581192 |
Elizabeth Dao1, Ging-Yuek Robin Hsiung2, Vesna Sossi3, Claudia Jacova4, Roger Tam5,6, Katie Dinelle7, John R Best1, Teresa Liu-Ambrose8,9.
Abstract
Entities:
Year: 2016 PMID: 27581192 PMCID: PMC5007817 DOI: 10.1186/s12883-016-0673-5
Source DB: PubMed Journal: BMC Neurol ISSN: 1471-2377 Impact factor: 2.474
Descriptive characteristic
| Variable | Mean | SD |
|---|---|---|
| Age | 71.73 | 7.91 |
| Female Sex, No. (%) | 7 | 32 |
| Education, No. (%) | ||
| High school education | 6 | 27 |
| Trade or professional certificate or diploma | 2 | 9 |
| University education | 14 | 64 |
| MMSE (max. score 30) | 27.50 | 1.95 |
| MOCA (max. score 30) | 23.32 | 2.08 |
| WHR | 0.91 | 0.08 |
| BMI | 26.95 | 4.78 |
| PIB-positive, No. (%) | 6 | 27.27 |
| Global PIB BPND | 0.07 | 0.23 |
| WML volume (mm3), | 2004.40 | 2761.15 |
| Cognitive Assessments | ||
| ADAS-Cog (max. score 70) | 9.63 | 3.88 |
| Exit-25 (max. score 50) | 10.59 | 4.38 |
| Stroop CW-C, sec. | 61.44 | 26.01 |
| Trails B-A, sec. | 50.51 | 24.84 |
| Digits F-B, sec. | 3.23 | 2.79 |
SD Standard Deviation, MMSE Mini-Mental State Examination, MOCA Montreal Cognitive Assessment; WHR Waist-to-Hip Ratio, BMI Body Mass Index, ADAS-Cog Alzheimer’s Disease Assessment Scale – Cognitive subscale, Exit-25 Executive Interview Test, Stroop CW-W Stroop Color Words minus Stroop colored x’s, Trails B-A Trails B (numbers and letters) minus Trails A (numbers), Digits F-B Digits Forwards minus Digits Backwards
Correlation matrix
| PIB BPND | Age | Education | APOE ε4 | ADAS-Cog | MOCA | EXIT 25 | Digits | Stroop | Trails | |
|---|---|---|---|---|---|---|---|---|---|---|
| PIB BPND | ||||||||||
| Age | -0.00 | |||||||||
| Education | -0.23 | -0.39 | ||||||||
| APOE ε4 | 0.36 | 0.09 | -0.20 | |||||||
| ADAS-Cog | 0.53* | 0.16 | -0.11 | 0.53* | ||||||
| MOCA | -0.54* | -0.20 | 0.06 | -0.11 | -0.45* | |||||
| EXIT-25 | 0.13 | 0.20 | -0.20 | 0.25 | 0.49* | -0.52* | ||||
| Digits | 0.02 | 0.17 | -0.35 | -0.45* | -0.30 | 0.13 | -0.04 | |||
| Stroop | 0.17 | -0.06 | 0.02 | -0.11 | 0.27 | -0.29 | 0.34 | 0.04 | ||
| Trails | 0.19 | -0.08 | -0.25 | 0.48* | 0.15 | -0.18 | 0.29 | 0.01 | 0.13 |
*significant at p ≤ 0.05
Multiple linear regression models assessing the contribution of PIB retention on ADAS-Cog
| Independent variables | R2 | Adjusted R2 | R2 Change | Unstandardized B (Standard Error) | Standardized β |
|
|---|---|---|---|---|---|---|
| Model 1 | ||||||
| PIB BPND | 0.28 | 0.24 | - | 9.09 (3.29) | 0.53 | 0.01 |
| Model 2 | ||||||
| Step 1 | 0.30 | 0.18 | 0.30 | |||
| Age | 0.07 (0.11) | 0.14 | 0.54 | |||
| Education | 0.41 (1.86) | 0.05 | 0.83 | |||
| APOE ε4 | 4.30 (1.64) | 0.53 | 0.02 | |||
| Step 2 | 0.44 | 0.31 | 0.15* | |||
| Age | 0.09 (0.10) | 0.18 | 0.37 | |||
| Education | 1.15 (1.74) | 0.14 | 0.52 | |||
| APOE ε4 | 3.20 (1.59) | 0.39 | 0.06 | |||
| PIB BPND | 7.23 (3.42) | 0.42 | 0.05 | |||
*significant at p ≤ 0.05
Multiple linear regression models assessing the contribution of PIB retention on MOCA
| Independent variables | R2 | Adjusted R2 | R2 Change | Unstandardized B (Standard Error) | Standardized β |
|
|---|---|---|---|---|---|---|
| Model 1 | ||||||
| PIB BPND | 0.29 | 0.26 | - | -5.00 (1.74) | -0.54 | 0.01 |
| Model 2 | ||||||
| Step 1 | 0.05 | -0.11 | 0.05 | |||
| Age | -0.06 (0.07) | -0.21 | 0.41 | |||
| Education | -0.22 (1.16) | -0.05 | 0.85 | |||
| APOE ε4 | -0.43 (1.02) | -0.10 | 0.68 | |||
| Step 2 | 0.37 | 0.22 | 0.32* | |||
| Age | -0.07 (0.06) | -0.28 | 0.20 | |||
| Education | -0.80 (0.99) | -0.18 | 0.43 | |||
| APOE ε4 | 0.44 (0.91) | 0.10 | 0.63 | |||
| PIB BPND | -5.71 (1.95) | -0.62 | 0.01 | |||
*significant at p ≤ 0.05