Laufey Hrolfsdottir1,2, Casper G Schalkwijk3, Bryndis E Birgisdottir4, Ingibjorg Gunnarsdottir4, Ekaterina Maslova5,6,7, Charlotta Granström5, Marin Strøm5,8, Sjurdur F Olsen5,9, Thorhallur I Halldorsson4,5. 1. Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. lah10@hi.is. 2. Department of Epidemiology Research, Centre for Fetal Programming, Statens Serum Institute, Copenhagen, Denmark. lah10@hi.is. 3. Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastrich University Medical Center, The Netherlands. 4. Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. 5. Department of Epidemiology Research, Centre for Fetal Programming, Statens Serum Institute, Copenhagen, Denmark. 6. Department of Epidemiology and Biostatistics, Imperial College, London, UK. 7. Danish Diabetes Academy, Odense, Denmark. 8. Faculty of Natural and Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands. 9. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Abstract
OBJECTIVE: To examine the associations of gestational weight gain (GWG) and diet with low-grade inflammation in pregnancy. METHODS: A cross-sectional analysis of 671 pregnant women was performed, and diet was assessed in gestational week 30. GWG was recorded in weeks 30 and ∼37 (difference between the weight recorded at these time points and pre-pregnancy weight). Markers of inflammation, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor-α were quantified in serum from week 30. RESULTS: After adjusting for age, pre-pregnancy BMI, parity, smoking status, and education, each 1 kg increase in GWG was associated with 3% (95% CI: 1-5) higher hsCRP and 3% (95% CI: 1-4) higher SAA concentrations, which corresponded to ∼18% to 25% increase in these biomarkers among those with excessive weight gain. GWG was inversely associated with IL-8 while no associations were found for the other inflammatory markers. With respect to diet, women in the highest compared with lowest quintile of protein intake had 26% (95% CI: 3-54) higher hsCRP concentrations. This increase appeared to be driven by intake of animal protein. A similar pattern was observed for SAA. CONCLUSIONS: Excessive GWG, as well as high intake of animal protein, was associated with higher concentrations of inflammatory factors.
OBJECTIVE: To examine the associations of gestational weight gain (GWG) and diet with low-grade inflammation in pregnancy. METHODS: A cross-sectional analysis of 671 pregnant women was performed, and diet was assessed in gestational week 30. GWG was recorded in weeks 30 and ∼37 (difference between the weight recorded at these time points and pre-pregnancy weight). Markers of inflammation, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor-α were quantified in serum from week 30. RESULTS: After adjusting for age, pre-pregnancy BMI, parity, smoking status, and education, each 1 kg increase in GWG was associated with 3% (95% CI: 1-5) higher hsCRP and 3% (95% CI: 1-4) higher SAA concentrations, which corresponded to ∼18% to 25% increase in these biomarkers among those with excessive weight gain. GWG was inversely associated with IL-8 while no associations were found for the other inflammatory markers. With respect to diet, women in the highest compared with lowest quintile of protein intake had 26% (95% CI: 3-54) higher hsCRP concentrations. This increase appeared to be driven by intake of animal protein. A similar pattern was observed for SAA. CONCLUSIONS: Excessive GWG, as well as high intake of animal protein, was associated with higher concentrations of inflammatory factors.
Authors: Aaron M Drucker; Eliza I Pope; Alison E Field; Abrar A Qureshi; Orianne Dumas; Carlos A Camargo Journal: J Allergy Clin Immunol Pract Date: 2018-11-08
Authors: Jennifer A Hutcheon; Olof Stephansson; Sven Cnattingius; Lisa M Bodnar; Anna-Karin Wikström; Kari Johansson Journal: Hypertension Date: 2018-06-18 Impact factor: 10.190
Authors: Brianna F Moore; Katherine A Sauder; Anne P Starling; James R Hébert; Nitin Shivappa; Brandy M Ringham; Deborah H Glueck; Dana Dabelea Journal: J Pediatr Date: 2017-12-06 Impact factor: 4.406
Authors: Hanna Danielewicz; Artur Gurgul; Anna Dębińska; Grzegorz Myszczyszyn; Tomasz Szmatoła; Anna Myszkal; Igor Jasielczuk; Anna Drabik-Chamerska; Lidia Hirnle; Andrzej Boznański Journal: Epigenetics Date: 2020-09-09 Impact factor: 4.528
Authors: Reyna Sámano; Hugo Martínez-Rojano; Rosa M Hernández; Cristina Ramírez; María E Flores Quijano; José M Espíndola-Polis; Daniela Veruete Journal: Nutrients Date: 2017-01-01 Impact factor: 5.717
Authors: Kathleen M Antony; Mona Romezi; Kourtnee Lindgren; Kristen B Mitchell; Susan F Venable; Diana A Racusin; Melissa A Suter; Kjersti M Aagaard Journal: Am J Perinatol Date: 2020-03-31 Impact factor: 1.862