Literature DB >> 27581025

Intravital Microscopy for Imaging the Tumor Microenvironment in Live Mice.

Victor Naumenko1,2,3,4, Craig Jenne5,6, Douglas J Mahoney7,8,9.   

Abstract

The development of intravital microscopy has provided unprecedented capacity to study the tumor microenvironment in live mice. The dynamic behavior of cancer, stromal, vascular, and immune cells can be monitored in real time, in situ, in both primary tumors and metastatic lesions, allowing treatment responses to be observed at single cell resolution and therapies tracked in vivo. These features provide a unique opportunity to elucidate the cellular mechanisms underlying the biology and treatment of cancer. We describe here a method for imaging the microenvironment of subcutaneous tumors grown in mice using intravital microscopy.

Entities:  

Keywords:  Confocal imaging; Intravital microscopy; Mouse models; Multiphoton imaging; Subcutaneous tumors; Tumor microenvironment

Mesh：

Year:  2016        PMID： 27581025     DOI： 10.1007/978-1-4939-3801-8_16

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  5 in total

1.  Intravital Microscopy Techniques to Image Wound Healing in Mouse Skin.

Authors:  Douglas J Mahoney; Craig N Jenne; Madison Turk; Jeff Biernaskie
Journal:  Methods Mol Biol       Date:  2022

2.  Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics.

Authors:  Maria V Efremova; Victor A Naumenko; Marina Spasova; Anastasiia S Garanina; Maxim A Abakumov; Anastasia D Blokhina; Pavel A Melnikov; Alexandra O Prelovskaya; Markus Heidelmann; Zi-An Li; Zheng Ma; Igor V Shchetinin; Yuri I Golovin; Igor I Kireev; Alexander G Savchenko; Vladimir P Chekhonin; Natalia L Klyachko; Michael Farle; Alexander G Majouga; Ulf Wiedwald
Journal:  Sci Rep       Date:  2018-07-26       Impact factor: 4.379

Review 3.  Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19.

Authors:  Manuela Teresa Raimondi; Francesca Donnaloja; Bianca Barzaghini; Alberto Bocconi; Claudio Conci; Valentina Parodi; Emanuela Jacchetti; Stephana Carelli
Journal:  Theranostics       Date:  2020-05-27       Impact factor: 11.556

4.  Tracking Cell Recruitment and Behavior within the Tumor Microenvironment Using Advanced Intravital Imaging Approaches.

Authors:  Madison Turk; Victor Naumenko; Douglas J Mahoney; Craig N Jenne
Journal:  Cells       Date:  2018-07-03       Impact factor: 6.600

5.  Visualizing Oncolytic Virus-Host Interactions in Live Mice Using Intravital Microscopy.

Authors:  Victor Naumenko; Shinia Van; Himika Dastidar; Dae-Sun Kim; Seok-Joo Kim; Zhutian Zeng; Justin Deniset; Arthur Lau; Chunfen Zhang; Nicolas Macia; Belinda Heyne; Craig N Jenne; Douglas J Mahoney
Journal:  Mol Ther Oncolytics       Date:  2018-07-14       Impact factor: 7.200
  5 in total

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