| Literature DB >> 27580904 |
T Berger1.
Abstract
In this review, the immune-to-brain communication pathways are briefly summarized, with emphasis on the impact of immune cells and their mediators on learning, memory and other cognitive domains. Further, the acute response of the central nervous system to peripherally generated inflammatory stimuli - termed as sickness behaviour - is described, and the central role of microglia in this immune-to-brain crosstalk in physiological and pathological conditions is highlighted. Finally, the role and consequences of immunological processes related to cognitive impairment in multiple sclerosis are discussed.Entities:
Keywords: cognition; cognitive impairment; immunology; multiple sclerosis; sickness behaviour
Mesh:
Year: 2016 PMID: 27580904 DOI: 10.1111/ane.12647
Source DB: PubMed Journal: Acta Neurol Scand ISSN: 0001-6314 Impact factor: 3.209