Literature DB >> 27579162

Role of milk fat globule-epidermal growth factor 8 in osteoimmunology.

Kathrin Sinningen1, Sylvia Thiele2, Lorenz C Hofbauer3, Martina Rauner2.   

Abstract

Milk fat globule-epidermal growth factor 8 (MFG-E8) is a glycoprotein that is abundantly expressed in various tissues and has a pivotal role in the phagocytic clearance of apoptotic cells. However, MFG-E8 has also gained significant attention because of its wide range of functions in autoimmunity, inflammation and tissue homeostasis. More recently, MFG-E8 has been identified as a critical regulator of bone homeostasis, being expressed in both, osteoblasts and osteoclasts. In addition, it was shown that MFG-E8 fulfils an active role in modulating inflammatory processes, suggesting an anti-inflammatory role of MFG-E8 and proposing it as a novel therapeutic target for inflammatory diseases. This concise review focusses on the expression and regulation of MFG-E8 in the context of inflammatory bone diseases, highlights its role in the pathophysiology of osteoimmune diseases and discusses the therapeutic potential of MFG-E8.

Entities:  

Year:  2016        PMID： 27579162      PMCID： PMC4954605          DOI： 10.1038/bonekey.2016.52

Source DB:  PubMed          Journal:  Bonekey Rep        ISSN： 2047-6396


  50 in total

1.  Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis.

Authors:  Michael Miksa; Rongqian Wu; Weifeng Dong; Padmalaya Das; Derek Yang; Ping Wang
Journal:  Shock       Date:  2006-06       Impact factor: 3.454

Review 2.  Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation.

Authors:  Monowar Aziz; Asha Jacob; Akihisa Matsuda; Ping Wang
Journal:  Apoptosis       Date:  2011-11       Impact factor: 4.677

3.  The roles of a novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8, in patients with coronary atherosclerotic heart disease.

Authors:  Wen Dai; Yan Li; Yong-Nan Lv; Chuan-Dong Wei; Hong-Yun Zheng
Journal:  Atherosclerosis       Date:  2014-01-22       Impact factor: 5.162

4.  Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.

Authors:  Toshiharu Abe; Jieun Shin; Kavita Hosur; Mark C Udey; Triantafyllos Chavakis; George Hajishengallis
Journal:  J Immunol       Date:  2014-06-23       Impact factor: 5.422

5.  Identification of a factor that links apoptotic cells to phagocytes.

Authors:  Rikinari Hanayama; Masato Tanaka; Keiko Miwa; Azusa Shinohara; Akihiro Iwamatsu; Shigekazu Nagata
Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

6.  Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2.

Authors:  Monowar Aziz; Akihisa Matsuda; Weng-Lang Yang; Asha Jacob; Ping Wang
Journal:  J Immunol       Date:  2012-05-25       Impact factor: 5.422

7.  Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner.

Authors:  Jan Kranich; Nike Julia Krautler; Jeppe Falsig; Boris Ballmer; Shulei Li; Gregor Hutter; Petra Schwarz; Rita Moos; Christian Julius; Gino Miele; Adriano Aguzzi
Journal:  J Exp Med       Date:  2010-09-13       Impact factor: 14.307

8.  Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.

Authors:  Stephanie Lefèvre; Anette Knedla; Christoph Tennie; Andreas Kampmann; Christina Wunrau; Robert Dinser; Adelheid Korb; Eva-Maria Schnäker; Ingo H Tarner; Paul D Robbins; Christopher H Evans; Henning Stürz; Jürgen Steinmeyer; Steffen Gay; Jürgen Schölmerich; Thomas Pap; Ulf Müller-Ladner; Elena Neumann
Journal:  Nat Med       Date:  2009-11-08       Impact factor: 53.440

9.  Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human.

Authors:  C Y Hu; C S Wu; H F Tsai; S K Chang; W I Tsai; P N Hsu
Journal:  Lupus       Date:  2009-07       Impact factor: 2.911

10.  Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus.

Authors:  M Herrmann; R E Voll; O M Zoller; M Hagenhofer; B B Ponner; J R Kalden
Journal:  Arthritis Rheum       Date:  1998-07
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  2 in total

1.  Synovial fluid and plasma levels of milk fat globule-epidermal growth factor 8 are inversely correlated with radiographic severity of knee osteoarthritis.

Authors:  Feihu Chen; Hao Liu; Jie Xia; Xiaomin Ding; Jianbo Fan; Xinhui Zhu; Shengyu Cui; Hong Yi; Rufeng Gao; Wei Liu
Journal:  J Int Med Res       Date:  2019-07-25       Impact factor: 1.671

2.  Proteomic analysis of plasma exosomes in patients with non-small cell lung cancer.

Authors:  Minwei Bao; Yuxia Huang; Zhongping Lang; Hui Zhao; Yuichi Saito; Tatsuya Nagano; Izumi Kawagoe; Duilio Divisi; Xiaoyi Hu; Gening Jiang
Journal:  Transl Lung Cancer Res       Date:  2022-07
  2 in total

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