Aldo Maina1, Tullia Todros1. 1. Dipartimento di Ostetricia e Neonatologia, Servizio di Medicina Interna, Ospedale Sant'Anna, Università di Torino , Torino , Italy.
Abstract
OBJECTIVE: A preliminary report on the symptomatic effect of clonidine in severe hyperemesis gravidarum (HG). DESIGN: Observational. SETTTING: Hospital based: Ospedale Sant'Anna, Torino, Italy. POPULATION: Twelve pregnant women, 8-16 weeks, affected by severe, refractory HG. METHODS: Assessment by two clinical score indexes: Pregnancy Unique Quantification of Emesis (PUQE) score and a Visual Analogue Scale (VAS) 5-item questionnaire, filled out daily, to detect subjective improvement or worsening of symptoms. MAIN OUTCOME MEASURES: PUQE score and VAS score before and after transdermal clonidine treatment. RESULTS: We found substantial improvement of symptoms and severity score indexes after four and 14 days. The comparison of pretreatment and post-treatment scores shows a significant statistical difference P < 0.0001. CONCLUSION: Transdermal clonidine may be considered as a treatment for resistant severe HG.
OBJECTIVE: A preliminary report on the symptomatic effect of clonidine in severe hyperemesis gravidarum (HG). DESIGN: Observational. SETTTING: Hospital based: Ospedale Sant'Anna, Torino, Italy. POPULATION: Twelve pregnant women, 8-16 weeks, affected by severe, refractory HG. METHODS: Assessment by two clinical score indexes: Pregnancy Unique Quantification of Emesis (PUQE) score and a Visual Analogue Scale (VAS) 5-item questionnaire, filled out daily, to detect subjective improvement or worsening of symptoms. MAIN OUTCOME MEASURES: PUQE score and VAS score before and after transdermal clonidine treatment. RESULTS: We found substantial improvement of symptoms and severity score indexes after four and 14 days. The comparison of pretreatment and post-treatment scores shows a significant statistical difference P < 0.0001. CONCLUSION: Transdermal clonidine may be considered as a treatment for resistant severe HG.
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