Literature DB >> 27579062

A longitudinal study of the effect of heparin thromboprophylaxis during pregnancy on maternal bone metabolism.

O Ogueh1, M R Johnson2, A Benjamin1.   

Abstract

The aim of this study was to determine the effect of heparin thromboprophylaxis during pregnancy on maternal biochemical markers of bone metabolism. This was a prospective longitudinal study of carboxy terminal pro-peptide of type I collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) levels in 15 women, who had heparin thromboprophylaxis during pregnancy compared with those of 18 normal pregnant controls. During pregnancy, the rate of change of PICP and ICTP in women who had heparin thromboprophylaxis was similar to those of women who did not (P = 0.184 for PICP, and P = 0.129 for ICTP), and PICP and ICTP levels at individual time points were similar in both groups. Therefore, heparin thromboprophylaxis during pregnancy does not affect maternal biochemical markers of bone metabolism.

Entities:  

Keywords:  ICTP; PICP; heparin; pregnancy

Year:  2009        PMID： 27579062      PMCID： PMC4989670          DOI： 10.1258/om.2009.090047

Source DB:  PubMed          Journal:  Obstet Med        ISSN： 1753-495X


  25 in total

1.  Biochemical markers of bone turnover during pregnancy: a longitudinal study.

Authors:  L Hellmeyer; V Ziller; G Anderer; A Ossendorf; S Schmidt; P Hadji
Journal:  Exp Clin Endocrinol Diabetes       Date:  2006-10       Impact factor: 2.949

2.  Changes in bone mass as determined by ultrasound and biochemical markers of bone turnover during pregnancy and puerperium: a longitudinal study.

Authors:  A Yamaga; M Taga; H Minaguchi; K Sato
Journal:  J Clin Endocrinol Metab       Date:  1996-02       Impact factor: 5.958

3.  Short-term low-dose heparin plus bedrest impairs bone metabolism in pregnant women.

Authors:  Ursula von Mandach; Franziska Aebersold; Renate Huch; Albert Huch
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2003-01-10       Impact factor: 2.435

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Authors:  M Backos; R Rai; E Thomas; M Murphy; C Doré; L Regan
Journal:  Hum Reprod       Date:  1999-11       Impact factor: 6.918

5.  Bone mineral density during long-term prophylaxis with heparin in pregnancy.

Authors:  T C Dahlman; H E Sjöberg; H Ringertz
Journal:  Am J Obstet Gynecol       Date:  1994-05       Impact factor: 8.661

6.  Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)

Authors:  R Rai; H Cohen; M Dave; L Regan
Journal:  BMJ       Date:  1997-01-25

7.  Effects of short-term low-dose heparin administration on biochemical parameters of bone turnover.

Authors:  H E van der Wiel; P Lips; P C Huijgens; J C Netelenbos
Journal:  Bone Miner       Date:  1993-07

8.  Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience.

Authors:  D W Branch; R M Silver; J L Blackwell; J C Reading; J R Scott
Journal:  Obstet Gynecol       Date:  1992-10       Impact factor: 7.661

9.  Prospective observational study of bone mineral density during pregnancy: low molecular weight heparin versus control.

Authors:  A J Carlin; R G Farquharson; S M Quenby; J Topping; W D Fraser
Journal:  Hum Reprod       Date:  2004-04-07       Impact factor: 6.918

10.  Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen.

Authors:  J Melkko; S Niemi; L Risteli; J Risteli
Journal:  Clin Chem       Date:  1990-07       Impact factor: 8.327
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