Literature DB >> 2757885

Effect of an inhaled mast cell stabiliser, N-acetyl-aspartyl-glutamate (Zy15109) on allergen-induced immediate bronchoconstriction.

C K Lai1, J Gregory, S T Holgate.   

Abstract

We have studied the effect of a mast cell stabiliser, the magnesium salt of N-acetyl aspartyl glutamic acid (NAAGA) on allergen-induced immediate bronchoconstriction in 12 atopic subjects. Inhaled NAAGA, at a dose of 60 mg thrice daily for 1 week, offered no protective effect on the airways against allergen challenge when compared with a matched placebo. The drug was well tolerated with no adverse effects observed.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2757885      PMCID： PMC1379930          DOI： 10.1111/j.1365-2125.1989.tb03427.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  10 in total

1.  Standardization of bronchial inhalation challenge procedures.

Authors:  H Chai; R S Farr; L A Froehlich; D A Mathison; J A McLean; R R Rosenthal; A L Sheffer; S L Spector; R G Townley
Journal:  J Allergy Clin Immunol       Date:  1975-10       Impact factor: 10.793

2.  Is inhibition of mast cell mediator release relevant to the clinical activity of anti-allergic drugs?

Authors:  M K Church
Journal:  Agents Actions       Date:  1986-06

3.  Prostaglandin D2 release from human skin mast cells in response to ionophore A23187.

Authors:  R C Benyon; C Robinson; S T Holgate; M K Church
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

4.  Pharmacological modulation of histamine release from choroidal mast cells induced by N-acetyl-aspartil-glutamic acid (MgNAAGA).

Authors:  A G Secchi; M R Angi; C Corbetta
Journal:  Farmaco Prat       Date:  1987-11

5.  Characterization of histamine secretion from mechanically dispersed human lung mast cells: effects of anti-IgE, calcium ionophore A23187, compound 48/80, and basic polypeptides.

Authors:  M K Church; G J Pao; S T Holgate
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

6.  Isolation, purification, and probable structural configuration of N-acetyl aspartyl glutamate in human brain.

Authors:  J V Auditore; E J Olson; L Wade
Journal:  Arch Biochem Biophys       Date:  1966-06       Impact factor: 4.013

7.  The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine 5' monophosphate in atopic asthma.

Authors:  P Rafferty; R Beasley; S T Holgate
Journal:  Am Rev Respir Dis       Date:  1987-08

8.  Mucosal mast cells. II. Effects of anti-allergic compounds on histamine secretion by isolated intestinal mast cells.

Authors:  F L Pearce; A D Befus; J Gauldie; J Bienenstock
Journal:  J Immunol       Date:  1982-06       Impact factor: 5.422

9.  A preliminary evaluation of the effect of N-acetyl-aspartyl-glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology.

Authors:  A Ghaem
Journal:  Allergy       Date:  1987-11       Impact factor: 13.146

10.  Histamine secretion from human skin slices induced by anti-IgE and artificial secretagogues and the effects of sodium cromoglycate and salbutamol.

Authors:  L S Clegg; M K Church; S T Holgate
Journal:  Clin Allergy       Date:  1985-07
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.