Amani Al-Rawashdeh1, Violet Kasabri2, Nailya Bulatova1, Amal Akour1, Ayman Zayed1, Munther Momani1, Nahla Khawaja3, Haider Bustanji3, Dana Hyasat3. 1. School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan. 2. School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan. Electronic address: violetk70@gmail.com. 3. National Center for Diabetes, Endocrinology and Genetics, Queen Rania Street, ox Amman 13165, Jordan.
Abstract
BACKGROUND: Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients. METHODS: The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N=89) as compared to MS-non-diabetic (N=69) patients. Competitive binding ELISA was used to evaluate betatrophin and OXT plasma concentrations. Correlations of the above biomarkers and patient clinical characteristics were also detected. RESULTS: As compared to the control MS participants (0.32±0.25ng/mL); betatrophin plasma levels were increased (P<0.001) in the MS-pre/T2DM patients (1.23±0.68ng/mL). On the contrary, OXT concentrations were decreased (P<0.001) in the MS-pre/T2DM patients (1222.46±514.55pg/mL) as compared to the MS control subjects (2323.42±848.68pg/mL). OXT concentration correlated negatively (r=-0.492, P<0.001), while HbA1c and FPG correlated positively with betatrophin plasma levels (P<0.001), but were inversely correlated with OXT levels (P<0.001) in the total sample. CONCLUSION: Betatrophin levels are increased, while OXT levels are decreased in MS-pre/T2DM. We found an inverse correlation between the levels of the two biomarkers in addition to correlation between their levels and the degree of glycemic control.
BACKGROUND:Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetespatients. METHODS: The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N=89) as compared to MS-non-diabetic (N=69) patients. Competitive binding ELISA was used to evaluate betatrophin and OXT plasma concentrations. Correlations of the above biomarkers and patient clinical characteristics were also detected. RESULTS: As compared to the control MS participants (0.32±0.25ng/mL); betatrophin plasma levels were increased (P<0.001) in the MS-pre/T2DM patients (1.23±0.68ng/mL). On the contrary, OXT concentrations were decreased (P<0.001) in the MS-pre/T2DM patients (1222.46±514.55pg/mL) as compared to the MS control subjects (2323.42±848.68pg/mL). OXT concentration correlated negatively (r=-0.492, P<0.001), while HbA1c and FPG correlated positively with betatrophin plasma levels (P<0.001), but were inversely correlated with OXT levels (P<0.001) in the total sample. CONCLUSION:Betatrophin levels are increased, while OXT levels are decreased in MS-pre/T2DM. We found an inverse correlation between the levels of the two biomarkers in addition to correlation between their levels and the degree of glycemic control.
Authors: Wesam Alsaud; Mohammad J Tabbaa; Violet N Kasabri; Maysa F Suyagh; Muneer A Abu Alsamen; Hussain M Haddad; Anas O ALshweki Journal: J Saudi Heart Assoc Date: 2020-08-03
Authors: Yuval Eisenberg; Lara R Dugas; Arfana Akbar; Bharathi Reddivari; Brian T Layden; Elena Barengolts Journal: PLoS One Date: 2018-01-04 Impact factor: 3.240