Literature DB >> 27578447

Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging.

Anna Pink1, Scott A Przybelski1, Janina Krell-Roesch1, Gorazd B Stokin1, Rosebud O Roberts1, Michelle M Mielke1, Kathleen A Spangehl1, David S Knopman1, Clifford R Jack1, Ronald C Petersen1, Yonas E Geda1.   

Abstract

The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged ≥70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.

Entities:  

Keywords:  Biological Markers; Neuropsychology

Mesh：

Substances：

Year:  2016        PMID： 27578447      PMCID： PMC5473777          DOI： 10.1176/appi.neuropsych.15100378

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN： 0895-0172            Impact factor:   2.198


  36 in total

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