T Hang Nghiem-Rao1, Allison F Dahlgren2, Deepti Kalluri3, Yumei Cao2, Pippa M Simpson2, Shailendra B Patel4. 1. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: hnghiem@mcw.edu. 2. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. 3. Department of Pediatrics, Albert Einstein College of Medicine, New York, NY, USA. 4. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA.
Abstract
BACKGROUND: Premature and critically ill infants receiving total parenteral nutrition (TPN) are at risk for dyslipidemia, and altered cholesterol levels in early life may contribute to later cardiovascular risk. Data regarding plasma cholesterol response to TPN in young infants are lacking. OBJECTIVE: To determine the changes in plasma cholesterol levels during the first week of life in infants receiving TPN and a comparison group of infants who did not receive TPN during routine care. METHODS: In a prospective, pilot cohort study, 38 neonates (30 TPN vs. 8 No-TPN) underwent serial blood sampling during the first week of life. Gas chromatography-mass spectrometry was used to measure cholesterol in plasma and TPN administered to study participants. RESULTS: Baseline cholesterol level was similar between groups. In contrast to infants who did not receive TPN, cholesterol levels during the first week of life were significantly higher than baseline in infants receiving TPN (maximum cholesterol response 34% vs. 103% change from baseline, No-TPN vs. TPN, respectively, P = .036). After adjusting for cumulative cholesterol received by infants receiving TPN, maximum cholesterol response remained inversely related to gestational age and birth weight (P < .05). CONCLUSION: Plasma cholesterol significantly increases during the first week of life in neonates receiving TPN. A higher cholesterol response was induced by TPN in infants of lower gestational age and birth weight.
BACKGROUND: Premature and critically ill infants receiving total parenteral nutrition (TPN) are at risk for dyslipidemia, and altered cholesterol levels in early life may contribute to later cardiovascular risk. Data regarding plasma cholesterol response to TPN in young infants are lacking. OBJECTIVE: To determine the changes in plasma cholesterol levels during the first week of life in infants receiving TPN and a comparison group of infants who did not receive TPN during routine care. METHODS: In a prospective, pilot cohort study, 38 neonates (30 TPN vs. 8 No-TPN) underwent serial blood sampling during the first week of life. Gas chromatography-mass spectrometry was used to measure cholesterol in plasma and TPN administered to study participants. RESULTS: Baseline cholesterol level was similar between groups. In contrast to infants who did not receive TPN, cholesterol levels during the first week of life were significantly higher than baseline in infants receiving TPN (maximum cholesterol response 34% vs. 103% change from baseline, No-TPN vs. TPN, respectively, P = .036). After adjusting for cumulative cholesterol received by infants receiving TPN, maximum cholesterol response remained inversely related to gestational age and birth weight (P < .05). CONCLUSION: Plasma cholesterol significantly increases during the first week of life in neonates receiving TPN. A higher cholesterol response was induced by TPN in infants of lower gestational age and birth weight.
Authors: Wei Cai; Phillip C Calder; Maria F Cury-Boaventura; Elisabeth De Waele; Julie Jakubowski; Gary Zaloga Journal: Nutrients Date: 2018-06-15 Impact factor: 5.717
Authors: T Hang Nghiem-Rao; Courtney Pfeifer; Michelle Asuncion; Joshua Nord; Daniel Schill; Kirthi Pulakanti; Shailendra B Patel; Lisa A Cirillo; Sridhar Rao Journal: Sci Rep Date: 2021-06-11 Impact factor: 4.996