Literature DB >> 2757695

The [lactate]/[pyruvate] ratio and alcohol metabolism: experiments with naloxone in fasting normal male volunteers.

C J Morgan1, A A Badawy, D R Thomas, T G Dando, A Kirby.   

Abstract

Naloxone administration to fasting normal male volunteers reverses the acute ethanol-induced increase in the blood [lactate]/[pyruvate] ratio, but fails to lower blood-ethanol concentration. The results are discussed in relation to factors affecting ethanol elimination and the mechanism of antagonism of acute alcohol intoxication by naloxone.

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Year:  1989        PMID: 2757695

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN: 0735-0414            Impact factor:   2.826


  1 in total

1.  Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats.

Authors:  Rafael Koerich Varaschin; Gina Struffaldi Morato
Journal:  Psychopharmacology (Berl)       Date:  2009-06-09       Impact factor: 4.530

  1 in total

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