BACKGROUND: Health-related quality of life (HRQOL) is an important issue in the context of dementia care. The purpose of this study was to investigate the association between HRQOL and depressive symptoms in patients with subjective cognitive decline (SCD) and subtypes of mild cognitive impairment (MCI) and Alzheimer´s disease (AD). METHODS: In this cross-sectional, observational study, a control group and four experimental groups (SCD, non-amnestic MCI, amnesticMCI, AD) were compared. Neuropsychological measurers (NTBV) and psychological questionnaires were used for data collection. RESULTS: The control group scored higher than patients with SCD, naMCI, aMCI, or AD for the Mental Health Component Score (MHCS) of the Short Form of the Health Survey (SF-36). The Physical Health Component Score (PHCS) of the SF-36 differed only between some groups. Furthermore, cognitive variables were more strongly associated with the physical aspects of HRQOL, whereas depressive symptoms were more strongly related with the mental aspects of HRQOL. CONCLUSIONS: HRQOL and depressive symptoms are closely related in patients with cognitive impairments. Therefore, it is of great importance to assess patients with subjective impairment carefully in terms of depressive symptoms.
BACKGROUND: Health-related quality of life (HRQOL) is an important issue in the context of dementia care. The purpose of this study was to investigate the association between HRQOL and depressive symptoms in patients with subjective cognitive decline (SCD) and subtypes of mild cognitive impairment (MCI) and Alzheimer´s disease (AD). METHODS: In this cross-sectional, observational study, a control group and four experimental groups (SCD, non-amnestic MCI, amnesticMCI, AD) were compared. Neuropsychological measurers (NTBV) and psychological questionnaires were used for data collection. RESULTS: The control group scored higher than patients with SCD, naMCI, aMCI, or AD for the Mental Health Component Score (MHCS) of the Short Form of the Health Survey (SF-36). The Physical Health Component Score (PHCS) of the SF-36 differed only between some groups. Furthermore, cognitive variables were more strongly associated with the physical aspects of HRQOL, whereas depressive symptoms were more strongly related with the mental aspects of HRQOL. CONCLUSIONS: HRQOL and depressive symptoms are closely related in patients with cognitive impairments. Therefore, it is of great importance to assess patients with subjective impairment carefully in terms of depressive symptoms.
Authors: Niels Janssen; Ron L Handels; Anders Wimo; Riitta Antikainen; Tiina Laatikainen; Hilkka Soininen; Timo Strandberg; Jaakko Tuomilehto; Miia Kivipelto; Silvia M A A Evers; Frans R J Verhey; Tiia Ngandu Journal: J Alzheimers Dis Date: 2022 Impact factor: 4.160
Authors: Youssef H El-Hayek; Ryan E Wiley; Charles P Khoury; Ritesh P Daya; Clive Ballard; Alison R Evans; Michael Karran; José Luis Molinuevo; Matthew Norton; Alireza Atri Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Felix S Hussenoeder; Hans-Helmut König; Ines Conrad; Susanne Roehr; Angela Fuchs; Michael Pentzek; Horst Bickel; Edelgard Moesch; Siegfried Weyerer; Jochen Werle; Birgitt Wiese; Silke Mamone; Christian Brettschneider; Kathrin Heser; Luca Kleineidam; Hanna Kaduszkiewicz; Marion Eisele; Wolfgang Maier; Michael Wagner; Martin Scherer; Steffi G Riedel-Heller Journal: Qual Life Res Date: 2020-01-28 Impact factor: 4.147