BACKGROUND: Conventional biomarkers lack sensitivity and specificity for acute pulmonary Community (PAC). Procalcitonin (PCT) has been described in the literature for its usefulness in the PAC. The aim of our work was to study the contribution of the PCT in the positive diagnosis of PAC and in the initial assessment of the severity and the interest of CRP and PCT to distinguish lung infections from tuberculous origin of the PAC. METHODS: Prospective study of 100 middle-aged 45 years [16-82], admitted to our clinic for evaluation of lung opacity some of the reason for consultation. All patients with antibiotics before admission were excluded. We studied the clinical, radiological, biological and bacteriological characteristics of patients. RESULTS: The rate of PCT was significantly higher in PAC compared to TBC (p <0.001). The values of CRP and PCT were correlated to changes in the PAC. The mean values of CRP and PCT were higher for the most severe PAC and the difference was statistically significant for CRP and PCT between the two (p =0.01). The cut-off of CRP and PCT could discriminate a PAC values were 35 mg / l and 0.12 ng /ml. CONCLUSION: The PCT is a good marker for diagnosis and the prognosis of PAC. It permits to discriminate diagnosing CAP compared to tuberculosis.
BACKGROUND: Conventional biomarkers lack sensitivity and specificity for acute pulmonary Community (PAC). Procalcitonin (PCT) has been described in the literature for its usefulness in the PAC. The aim of our work was to study the contribution of the PCT in the positive diagnosis of PAC and in the initial assessment of the severity and the interest of CRP and PCT to distinguish lung infections from tuberculous origin of the PAC. METHODS: Prospective study of 100 middle-aged 45 years [16-82], admitted to our clinic for evaluation of lung opacity some of the reason for consultation. All patients with antibiotics before admission were excluded. We studied the clinical, radiological, biological and bacteriological characteristics of patients. RESULTS: The rate of PCT was significantly higher in PAC compared to TBC (p <0.001). The values of CRP and PCT were correlated to changes in the PAC. The mean values of CRP and PCT were higher for the most severe PAC and the difference was statistically significant for CRP and PCT between the two (p =0.01). The cut-off of CRP and PCT could discriminate a PAC values were 35 mg / l and 0.12 ng /ml. CONCLUSION: The PCT is a good marker for diagnosis and the prognosis of PAC. It permits to discriminate diagnosing CAP compared to tuberculosis.