| Literature DB >> 27575482 |
Ra-Yeong Choi1, Sang-Jip Nam2, Ju Ri Ham1, Hae-In Lee3, Sung-Tae Yee4, Kyung-Yun Kang5, Kwon-Il Seo6, Ju-Hye Lee7, Myung-Joo Kim8, Mi-Kyung Lee9.
Abstract
Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3',4'-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.Entities:
Keywords: Adipocytes; Adipogenesis; Anti-diabetes; Anti-obesity; Peucedanum japonicum Thunb leaves
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Year: 2016 PMID： 27575482 DOI： 10.1016/j.bmcl.2016.08.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823