| Literature DB >> 2757420 |
Abstract
We studied a series of 26 cases of carcinoma of the ampulla of Vater. There were 24 adenocarcinomas and two neuroendocrine tumors. Histologically the carcinomas could be divided into tumors arising from periampullary duodenal mucosa and those arising within the ampulla. True ampullary tumors had a significantly better 5-year survival rate (p = 0.028) than periampullary tumors. The type of mucin produced was investigated histochemically. Patients with true ampullary tumors producing predominantly sialomucins had a better prognosis than those with tumors secreting sulphated mucins (p = 0.045), but the numbers were small. We hypothesize that the most favorable type of ampullary carcinoma arises from biliary-type epithelium within the ampulla.Entities:
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Year: 1989 PMID: 2757420 PMCID: PMC1357824 DOI: 10.1097/00000658-198908000-00006
Source DB: PubMed Journal: Ann Surg ISSN: 0003-4932 Impact factor: 12.969