Literature DB >> 27573226

Trial watch: Impact of genetically supported target selection on R&D productivity.

Mark R Hurle1, Matthew R Nelson1, Pankaj Agarwal1, Lon R Cardon1.   

Abstract

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Year:  2016        PMID： 27573226     DOI： 10.1038/nrd.2016.164

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  1 in total

1.  The support of human genetic evidence for approved drug indications.

Authors:  Matthew R Nelson; Hannah Tipney; Jeffery L Painter; Judong Shen; Paola Nicoletti; Yufeng Shen; Aris Floratos; Pak Chung Sham; Mulin Jun Li; Junwen Wang; Lon R Cardon; John C Whittaker; Philippe Sanseau
Journal:  Nat Genet       Date:  2015-06-29       Impact factor: 38.330
  1 in total
  5 in total

Review 1.  Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future.

Authors:  Erik Ingelsson; Mark I McCarthy
Journal:  Circ Genom Precis Med       Date:  2018-06

2.  Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets.

Authors:  Andrew D Rouillard; Mark R Hurle; Pankaj Agarwal
Journal:  PLoS Comput Biol       Date:  2018-05-21       Impact factor: 4.475

3.  Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.

Authors:  Katerina Trajanoska; John A Morris; Ling Oei; Hou-Feng Zheng; David M Evans; Douglas P Kiel; Claes Ohlsson; J Brent Richards; Fernando Rivadeneira
Journal:  BMJ       Date:  2018-08-29

4.  Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

Authors:  Emily A King; J Wade Davis; Jacob F Degner
Journal:  PLoS Genet       Date:  2019-12-12       Impact factor: 5.917

Review 5.  Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches.

Authors:  Laura B L Wittemans; Luca A Lotta; Claudia Langenberg
Journal:  Curr Diab Rep       Date:  2018-05-19       Impact factor: 4.810
  5 in total

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