Zahra Shahhoseini1, Fereshteh Jeivad2, Nematollah Ahangar1, Saeid Abediankenari3. 1. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Science, Sari, Iran. 2. Department of Toxicology & Pharmacology, Tehran University of Medical Science, Tehran, Iran. 3. Immunogenetics Research Center, Mazandaran University of Medical Science, Sari, Iran. abedianks@alumnus.tums.ac.ir.
Abstract
PURPOSE: Octamer binding transcription factor B gene (OCT4) is responsible for development and self-renewal maintenance of embryonic stem cells. The rs3130932 single nucleotide polymorphism (SNP) may play a role in tumor genesis. Because of high prevalence of gastric cancer in north of Iran, this study was investigated role of rs3130932 polymorphism and stomach cancer. METHODS: Blood samples were collected from 100 informed gastric cancer patients and 100 age and sex-matched healthy individuals, and were genotyped for the presence of rs3130932G allele by ssp PCR. RESULTS: The mean age of participant (n = 200) was 67.83 ± 10.878 years. In genotyping and allelic analysis, TG genotype increased 66.147 times more likely to develop stomach cancer than the TT genotype, and disease risk increases 140.496 times more in GG genotype in comparison with TT genotype. CONCLUSION: This study clearly emphasis on different genetic profile in this population and show that the rs3130932G allele and odds of gastric cancer are related to each other in northern of Iran.
PURPOSE: Octamer binding transcription factor B gene (OCT4) is responsible for development and self-renewal maintenance of embryonic stem cells. The rs3130932 single nucleotide polymorphism (SNP) may play a role in tumor genesis. Because of high prevalence of gastric cancer in north of Iran, this study was investigated role of rs3130932 polymorphism and stomach cancer. METHODS: Blood samples were collected from 100 informed gastric cancerpatients and 100 age and sex-matched healthy individuals, and were genotyped for the presence of rs3130932G allele by ssp PCR. RESULTS: The mean age of participant (n = 200) was 67.83 ± 10.878 years. In genotyping and allelic analysis, TG genotype increased 66.147 times more likely to develop stomach cancer than the TT genotype, and disease risk increases 140.496 times more in GG genotype in comparison with TT genotype. CONCLUSION: This study clearly emphasis on different genetic profile in this population and show that the rs3130932G allele and odds of gastric cancer are related to each other in northern of Iran.
Entities:
Keywords:
Gastric cancer; OCT4 gene; Single nucleotide polymorphism
Authors: Jiabo Di; Tjitske Duiveman-de Boer; Petra L M Zusterzeel; Carl G Figdor; Leon F A G Massuger; Ruurd Torensma Journal: Cell Oncol (Dordr) Date: 2013-08-09 Impact factor: 6.730
Authors: Marina França de Resende; Ludmilla Thomé Domingos Chinen; Samantha Vieira; Juliano Jampietro; Francisco Paulo da Fonseca; José Vassallo; Luciene Cristina Campos; Gustavo Cardoso Guimarães; Fernando Augusto Soares; Rafael Malagoli Rocha Journal: Tumour Biol Date: 2013-05-01
Authors: Francesco Gianfagna; Emma De Feo; Cornelia M van Duijn; Gualtiero Ricciardi; Stefania Boccia Journal: Curr Genomics Date: 2008-09 Impact factor: 2.236