Literature DB >> 27572417

Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.

Sun Hee Lee1, Wan Beom Park2, Shinwon Lee3, Sohee Park1, Shin Woo Kim4, Jong-Myung Lee4, Hyun Ha Chang4, Ki Tae Kwon5, Pyoeng Gyun Choe2, Nam Joong Kim2, Hong Bin Kim6, Myoung-Don Oh2.   

Abstract

Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27572417      PMCID： PMC5075110          DOI： 10.1128/AAC.01517-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Prevalence of blaZ gene types and the inoculum effect with cefazolin among bloodstream isolates of methicillin-susceptible Staphylococcus aureus.

Authors:  D J Livorsi; E Crispell; S W Satola; E M Burd; R Jerris; Y F Wang; M M Farley
Journal:  Antimicrob Agents Chemother       Date:  2012-05-14       Impact factor: 5.191

3.  MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.

Authors:  Koichiro Tamura; Glen Stecher; Daniel Peterson; Alan Filipski; Sudhir Kumar
Journal:  Mol Biol Evol       Date:  2013-10-16       Impact factor: 16.240

4.  Clinical experiences with cefazolin and other cephalosporins in bacterial endocarditis.

Authors:  E L Quinn; D Pohlod; T Madhavan; K Burch; E Fisher; F Cox
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

5.  Staphylococcal beta-lactamase and efficacy of beta-lactam antibiotics: in vitro and in vivo evaluation.

Authors:  S W Chapman; R T Steigbigel
Journal:  J Infect Dis       Date:  1983-06       Impact factor: 5.226

6.  Is cefazolin inferior to nafcillin for treatment of methicillin-susceptible Staphylococcus aureus bacteremia?

Authors:  Shinwon Lee; Pyoeng Gyun Choe; Kyoung-Ho Song; Sang-Won Park; Hong Bin Kim; Nam Joong Kim; Eui-Chong Kim; Wan Beom Park; Myoung-Don Oh
Journal:  Antimicrob Agents Chemother       Date:  2011-08-08       Impact factor: 5.191

7.  Cefazolin high-inoculum effect in methicillin-susceptible Staphylococcus aureus from South American hospitals.

Authors:  Sandra Rincón; Jinnethe Reyes; Lina Paola Carvajal; Natalia Rojas; Fabián Cortés; Diana Panesso; Manuel Guzmán; Jeannete Zurita; Javier A Adachi; Barbara E Murray; Esteban C Nannini; Cesar A Arias
Journal:  J Antimicrob Chemother       Date:  2013-06-21       Impact factor: 5.790

8.  Comparative effectiveness of cefazolin versus cloxacillin as definitive antibiotic therapy for MSSA bacteraemia: results from a large multicentre cohort study.

Authors:  Anthony D Bai; Adrienne Showler; Lisa Burry; Marilyn Steinberg; Daniel R Ricciuto; Tania Fernandes; Anna Chiu; Sumit Raybardhan; Michelle Science; Eshan Fernando; George Tomlinson; Chaim M Bell; Andrew M Morris
Journal:  J Antimicrob Chemother       Date:  2015-01-21       Impact factor: 5.790

9.  Relapse of type A beta-lactamase-producing Staphylococcus aureus native valve endocarditis during cefazolin therapy: revisiting the issue.

Authors:  Esteban C Nannini; Kavindra V Singh; Barbara E Murray
Journal:  Clin Infect Dis       Date:  2003-10-01       Impact factor: 9.079

10.  Clinical implications of cefazolin inoculum effect and β-lactamase type on methicillin-susceptible Staphylococcus aureus bacteremia.

Authors:  Shinwon Lee; Ki Tae Kwon; Hye-In Kim; Hyun Ha Chang; Jong-Myung Lee; Pyoeng Gyun Choe; Wan Beom Park; Nam Joong Kim; Myoung-Don Oh; Do Young Song; Shin-Woo Kim
Journal:  Microb Drug Resist       Date:  2014-12       Impact factor: 3.431
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  3 in total

1.  Inoculum effect of β-lactam antibiotics.

Authors:  Justin R Lenhard; Zackery P Bulman
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

Review 2.  Efficacy and safety of cefazolin versus antistaphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia: a systematic review and meta-analysis.

Authors:  Changcheng Shi; Yubo Xiao; Qi Zhang; Qingyu Li; Fei Wang; Jing Wu; Nengming Lin
Journal:  BMC Infect Dis       Date:  2018-10-11       Impact factor: 3.090

3.  The Cefazolin Inoculum Effect and the Presence of type A blaZ Gene according to agr Genotype in Methicillin-Susceptible Staphylococcus aureus Bacteremia.

Authors:  Soon Ok Lee; Shinwon Lee; Sohee Park; Jeong Eun Lee; Sun Hee Lee
Journal:  Infect Chemother       Date:  2019-12
  3 in total

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