Literature DB >> 27571912

Inadvertent yellow fever vaccination of a patient with Crohn's disease treated with infliximab and methotrexate.

Christina Ekenberg1, Nina Friis-Møller1, Thomas Ulstrup2, Claus Aalykke2.   

Abstract

We present a case of a 56-year-old woman with Crohn's disease, treated with methotrexate and infliximab, who inadvertently received yellow fever vaccination (YFV) prior to a journey to Tanzania. She was not previously vaccinated against YF. YFV contains live-attenuated virus, and is contraindicated in patients treated with immunosuppressive drugs. Following vaccination, the patient fell ill with influenza-like illness. Elevated transaminase levels and YF viremia were detected. Despite being immunocompromised, the patient did not develop more severe adverse effects. Neutralising antibodies to YF virus were detected on day 14 following vaccination and remained protective at least 10 months after vaccination. Limited data is available on outcomes of YFV in patients receiving immunosuppressive therapy, including biologics, and we report this case as a reminder of vigilance of vaccine recommendations in this population. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID： 27571912      PMCID： PMC5015127          DOI： 10.1136/bcr-2016-215403

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


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Authors: 
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Review 9.  Determinants of health-related quality of life in Crohn's disease: a systematic review and meta-analysis.

Authors:  Mike van der Have; Karen S van der Aalst; Ad A Kaptein; Max Leenders; Peter D Siersema; Bas Oldenburg; Herma H Fidder
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10.  Comparison of the PRNT and an immune fluorescence assay in yellow fever vaccinees receiving immunosuppressive medication.

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