Literature DB >> 27571478

Genetic code expansion in the mouse brain.

Russell J Ernst1, Toke P Krogager1, Elizabeth S Maywood1, Roberto Zanchi1, Václav Beránek1, Thomas S Elliott1, Nicholas P Barry1, Michael H Hastings1, Jason W Chin1.   

Abstract

Site-specific incorporation of non-natural amino acids into proteins, via genetic code expansion with pyrrolysyl tRNA synthetase (PylRS) and tRNA(Pyl)CUA pairs (and their evolved derivatives) from Methanosarcina sp., forms the basis of powerful approaches to probe and control protein function in cells and invertebrate organisms. Here we demonstrate that adeno-associated viral delivery of these pairs enables efficient genetic code expansion in primary neuronal culture, organotypic brain slices and the brains of live mice.

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Year:  2016        PMID： 27571478      PMCID： PMC5215917          DOI： 10.1038/nchembio.2160

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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