Literature DB >> 27570414

Simultaneous, bilateral, complete atypical femoral fractures after long-term alendronate use.

Mark Higgins1, Sam Morgan-John1, Sachin Badhe1.   

Abstract

Over the past decade there have been increasing reports of atypical femoral fractures (AFFs) associated with bisphosphonate use. Reported cases of bilateral involvement usually refer to sequential injuries, or a complete fracture with an incomplete injury to the contralateral limb. In this case report we describe simultaneous, bilateral, complete atypical femoral fractures following a simple fall. A history of prodromal pain, previous radiological evidence of cortical thickening and long term alendronate therapy for osteoporosis secondary to corticosteroid treatment paint a classical picture of the presentation of an atypical fracture pattern of which orthopaedic surgeons should be aware.

Entities:  

Keywords:  Atypical femoral fracture; Bisphosphonate fracture; Subtrochanteric fracture

Year:  2016        PMID: 27570414      PMCID: PMC4990659          DOI: 10.1016/j.jor.2016.07.007

Source DB:  PubMed          Journal:  J Orthop        ISSN: 0972-978X


  9 in total

1.  Simultaneous bilateral atypical femoral fractures after alendronate therapy.

Authors:  C P Zafeiris; I P Stathopoulos; G Kourkoumelis; E Gkikas; G P Lyritis
Journal:  J Musculoskelet Neuronal Interact       Date:  2012-12       Impact factor: 2.041

2.  Atypical femoral fractures and bisphosphonate treatment: experience in two large United Kingdom teaching hospitals.

Authors:  R N Thompson; J R A Phillips; S H J McCauley; J R M Elliott; C G Moran
Journal:  J Bone Joint Surg Br       Date:  2012-03

3.  Case reports: subtrochanteric femoral stress fractures after prolonged alendronate therapy.

Authors:  Katerina Cermak; Felix Shumelinsky; Jean Alexiou; Michael J Gebhart
Journal:  Clin Orthop Relat Res       Date:  2009-12-18       Impact factor: 4.176

4.  Duration-dependent effects of clinically relevant oral alendronate doses on cortical bone toughness in beagle dogs.

Authors:  David B Burr; Ziyue Liu; Matthew R Allen
Journal:  Bone       Date:  2014-10-23       Impact factor: 4.398

5.  Femoral insufficiency fractures associated with prolonged bisphosphonate therapy.

Authors:  Joseph D Isaacs; Louis Shidiak; Ian A Harris; Zoltan L Szomor
Journal:  Clin Orthop Relat Res       Date:  2010-08-31       Impact factor: 4.176

Review 6.  Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research.

Authors:  Elizabeth Shane; David Burr; Bo Abrahamsen; Robert A Adler; Thomas D Brown; Angela M Cheung; Felicia Cosman; Jeffrey R Curtis; Richard Dell; David W Dempster; Peter R Ebeling; Thomas A Einhorn; Harry K Genant; Piet Geusens; Klaus Klaushofer; Joseph M Lane; Fergus McKiernan; Ross McKinney; Alvin Ng; Jeri Nieves; Regis O'Keefe; Socrates Papapoulos; Tet Sen Howe; Marjolein C H van der Meulen; Robert S Weinstein; Michael P Whyte
Journal:  J Bone Miner Res       Date:  2013-10-01       Impact factor: 6.741

7.  Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy.

Authors:  Craig M Capeci; Nirmal C Tejwani
Journal:  J Bone Joint Surg Am       Date:  2009-11       Impact factor: 5.284

8.  Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment.

Authors:  Matthew R Allen; Susan Reinwald; David B Burr
Journal:  Calcif Tissue Int       Date:  2008-05-08       Impact factor: 4.333

Review 9.  Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report.

Authors:  R Rizzoli; K Akesson; M Bouxsein; J A Kanis; N Napoli; S Papapoulos; J-Y Reginster; C Cooper
Journal:  Osteoporos Int       Date:  2010-11-18       Impact factor: 4.507

  9 in total
  2 in total

1.  Adult-onset hypophosphatasia diagnosed following bilateral atypical femoral fractures in a 55-year-old woman.

Authors:  John E Lawrence; Danish Saeed; Jonathan Bartlett; Andrew D Carrothers
Journal:  Clin Cases Miner Bone Metab       Date:  2017-12-27

2.  Bisphosphonate therapy associated with bilateral atypical femoral fracture and delayed union.

Authors:  István Gárgyán; Dávid Dózsai; István Csonka; Ferenc Rárosi; Tamás Bodzay; Ákos Csonka
Journal:  Jt Dis Relat Surg       Date:  2022-03-28
  2 in total

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