| Literature DB >> 27569725 |
Suk-Kyun Yang1, Myunghee Hong2, Hyunjung Oh2, Hui-Qi Low2, Seulgi Jung2, Seonjoo Ahn2, Youngjin Kim2, Jiwon Baek2, Cue Hyunkyu Lee3, Eunji Kim4, Kyung Mo Kim5, Byong Duk Ye1, Kyung-Jo Kim1, Sang Hyoung Park1, Ho-Su Lee1, Inchul Lee6, Hyoung Doo Shin7, Buhm Han3, Dermot P B McGovern8, Jianjun Liu9, Kyuyoung Song10.
Abstract
Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 × 10-4). Our findings support the complementary value of genetic studies in different populations. Copyright ÂEntities:
Keywords: Crohn’s Disease; Genetics; Risk Factor; Ulcerative Colitis
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Year: 2016 PMID： 27569725 DOI： 10.1053/j.gastro.2016.08.025
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682