| Literature DB >> 27569419 |
Gang Wang1, Luyang Cao1, Xiaowen Liu1, Nathan A Sieracki1, Anke Di1, Xi Wen2, Yong Chen3, Shalina Taylor1, Xiaojia Huang1, Chinnaswamy Tiruppathi1, You-Yang Zhao1, Yuanlin Song4, Xiaopei Gao1, Tian Jin2, Chunxue Bai4, Asrar B Malik1, Jingsong Xu5.
Abstract
Blood neutrophils perform an essential host-defense function by directly migrating to bacterial invasion sites to kill bacteria. The mechanisms mediating the transition from the migratory to bactericidal phenotype remain elusive. Here, we demonstrate that TRPM2, a trp superfamily member, senses neutrophil-generated reactive oxygen species and restrains neutrophil migration. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition. The oxidant sensing-induced termination of neutrophil migration at the site of infection permits a smooth transition to the subsequent microbial killing phase.Entities:
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Year: 2016 PMID： 27569419 PMCID： PMC5455786 DOI： 10.1016/j.devcel.2016.07.014
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270