Literature DB >> 27569398

Argonaute: The executor of small RNA function.

Azali Azlan1, Najat Dzaki1, Ghows Azzam2.   

Abstract

The discovery of small non-coding RNAs - microRNA (miRNA), short interfering RNA (siRNA) and PIWI-interacting RNA (piRNA) - represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation. In order to execute their functions, these small RNAs require physical interactions with their protein partners, the Argonaute (AGO) family proteins. Over the years, numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms. In this review, we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies, humans and other model organisms as compliment.
Copyright © 2016 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Argonaute; Drosophila melanogaster; Gene silencing; Human; Model organisms; RNAi; Small RNAs

Mesh：

Substances：

Year:  2016        PMID： 27569398     DOI： 10.1016/j.jgg.2016.06.002

Source DB:  PubMed          Journal:  J Genet Genomics        ISSN： 1673-8527            Impact factor:   4.275


  19 in total

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