Literature DB >> 2756924

Characterization of retinyl beta-glucuronide in human blood.

A B Barua1, R O Batres, J A Olson.   

Abstract

Retinyl beta-glucuronide has been identified as a normal endogenous component of human blood, as have retinoyl beta-glucuronide and retinoic acid. The mean serum concentration of retinyl beta-glucuronide in adult volunteers (n = 6) was 6.8 +/- 4.0 nmol/L (means +/- SD) with a range from 1 to 11 nmol/L. Purified serum retinyl beta-glucuronide was characterized by the mass spectrum of its methylated trimethylsilyl derivative, by its hydrolysis by beta-glucuronidase, and by its chromatographic behavior in high-performance liquid chromatography systems. During a single day, concentrations of retinyl beta-glucuronide, retinoyl beta-glucuronide, and retinoic acid varied approximately two-fold.

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Year:  1989        PMID: 2756924     DOI: 10.1093/ajcn/50.2.370

Source DB:  PubMed          Journal:  Am J Clin Nutr        ISSN: 0002-9165            Impact factor:   7.045


  9 in total

Review 1.  Retinol and retinyl esters: biochemistry and physiology.

Authors:  Sheila M O'Byrne; William S Blaner
Journal:  J Lipid Res       Date:  2013-04-26       Impact factor: 5.922

Review 2.  Clinical pharmacokinetics of tretinoin.

Authors:  M B Regazzi; I Iacona; C Gervasutti; M Lazzarino; S Toma
Journal:  Clin Pharmacokinet       Date:  1997-05       Impact factor: 6.447

3.  Chemical synthesis of all-trans-[11-3H]retinoyl beta-glucuronide and its metabolism in rats in vivo.

Authors:  A B Barua; J A Olson
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

Review 4.  Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.

Authors:  William S Blaner
Journal:  Pharmacol Ther       Date:  2019-01-29       Impact factor: 12.310

Review 5.  The multifaceted nature of retinoid transport and metabolism.

Authors:  Yang Li; Nuttaporn Wongsiriroj; William S Blaner
Journal:  Hepatobiliary Surg Nutr       Date:  2014-06       Impact factor: 7.293

6.  Time-Dependent Kinetics of Tretinoin in Chronic Myelogenous Leukaemia during Intermittent Dose Scheduling: 1 Week On/1 Week Off.

Authors:  M B Regazzi; D Russo; I Iacona; S Sacchi; G Visani; M Lazzarino; G Avvisati; P G Pelicci; G Dastoli; C Grandi; S Spreafico; R Grattoni; P Galieni; S Rupoli; A M Maiolo; E Guerra; A M Liberati
Journal:  Clin Drug Investig       Date:  1998       Impact factor: 2.859

Review 7.  Properties of retinoids. Structure, handling, and preparation.

Authors:  A B Barua; H C Furr
Journal:  Mol Biotechnol       Date:  1998-10       Impact factor: 2.695

8.  Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver.

Authors:  Renate Schreiber; Ulrike Taschler; Heimo Wolinski; Andrea Seper; Stefanie N Tamegger; Maria Graf; Sepp D Kohlwein; Guenter Haemmerle; Robert Zimmermann; Rudolf Zechner; Achim Lass
Journal:  J Lipid Res       Date:  2009-08-31       Impact factor: 5.922

Review 9.  Mechanisms of Feedback Regulation of Vitamin A Metabolism.

Authors:  Catherine O'Connor; Parisa Varshosaz; Alexander R Moise
Journal:  Nutrients       Date:  2022-03-21       Impact factor: 5.717

  9 in total

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