Ying Wang1, Shiming Tang1, Shunsheng Xu1, Shenhong Weng1, Zhongchun Liu2. 1. Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China. 2. Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Department of Psychiatry, Institution of Neuropsychiatry Research, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China. Electronic address: zcliu6@whu.edu.cn.
Abstract
BACKGROUND: Results of the relationships between diabetes and the risk of suicide death are inconclusive. This meta-analysis was conducted to assess this association. METHODS: We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library up to February 29, 2016 for relevant observational studies regarding the association between diabetes and risk of suicide. Random-effects models were used to calculate summary relative risk (RR) and 95% confidence interval (CI). RESULTS: 6 observational studies (8 independent reports) with a total of 3,075,214 participants and 3038 suicide deaths events were included in the meta-analysis. Overall, diabetes was not associated with risk of suicide deaths, with significant heterogeneity among studies observed (Summary RR=1.61, 95% CI: 0.91-2.83, Pheterogeneity<0.001, I2=97.2%). No publication bias was detected across studies, and both the subgroup analysis and sensitivity analysis suggested that the general result was robust. CONCLUSION: Our meta-analysis based on more than 3 million participants indicates that diabetes is not associated with increased risk of suicide death. Further well-designed prospective cohort studies are needed to confirm the findings of this meta-analysis.
BACKGROUND: Results of the relationships between diabetes and the risk of suicide death are inconclusive. This meta-analysis was conducted to assess this association. METHODS: We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library up to February 29, 2016 for relevant observational studies regarding the association between diabetes and risk of suicide. Random-effects models were used to calculate summary relative risk (RR) and 95% confidence interval (CI). RESULTS: 6 observational studies (8 independent reports) with a total of 3,075,214 participants and 3038 suicide deaths events were included in the meta-analysis. Overall, diabetes was not associated with risk of suicide deaths, with significant heterogeneity among studies observed (Summary RR=1.61, 95% CI: 0.91-2.83, Pheterogeneity<0.001, I2=97.2%). No publication bias was detected across studies, and both the subgroup analysis and sensitivity analysis suggested that the general result was robust. CONCLUSION: Our meta-analysis based on more than 3 million participants indicates that diabetes is not associated with increased risk of suicide death. Further well-designed prospective cohort studies are needed to confirm the findings of this meta-analysis.
Authors: Tania Guadalupe Gómez-Peralta; Thelma Beatriz González-Castro; Ana Fresan; Carlos Alfonso Tovilla-Zárate; Isela Esther Juárez-Rojop; Mario Villar-Soto; Yazmín Hernández-Díaz; María Lilia López-Narváez; Jorge L Ble-Castillo; Nonanzit Pérez-Hernández; José Manuel Rodríguez-Pérez Journal: Int J Environ Res Public Health Date: 2018-06-07 Impact factor: 3.390
Authors: John-Michael Gamble; Eugene Chibrikov; William K Midodzi; Laurie K Twells; Sumit R Majumdar Journal: BMJ Open Date: 2018-10-08 Impact factor: 2.692