Eun Hyun Seo1,2, Hoowon Kim1,3, Kun Ho Lee1,4, Il Han Choo1,5. 1. National Research Center for Dementia, Gwangju, Korea. 2. Premedical Science, College of Medicine, Chosun University, Gwangju, Korea. 3. Department of Neurology, School of Medicine, Chosun University/Chosun University Hospital, Gwangju, Korea. 4. College of Natural Sciences, Chosun University, Gwangju, South Korea. 5. Department of Neuropsychiatry, School of Medicine, Chosun University/Chosun University Hospital, Gwangju, Korea.
Abstract
BACKGROUND: For the early detection of Alzheimer's disease (AD), there is increasing interest in pre-mild cognitive impairment (pre-MCI). OBJECTIVE: We explored the neuropsychological characteristics in a group of pre-MCI and cognitively normal (CN) elderly individuals, with the aim of providing measures sensitive to cognitive change in pre-MCI. METHODS: We included 188 CN elderly and 77 individuals with pre-MCI. All participants underwent comprehensive clinical and neuropsychological assessment. We compared 17 cognitive tests between the CN and pre-MCI groups by using one-way ANOVAs with false discovery rate correction for multiple comparisons. Pearson's correlations were also obtained between episodic memory and executive function tests in the pre-MCI group. RESULTS: The pre-MCI group showed significantly lower scores for visual immediate recall, fluency tests, and Stroop color naming in the color-word incongruent condition than the CN group (p < 0.05). Most of these executive function measures were significantly correlated with episodic memory (p < 0.05). There were no significant group-differences in other tests assessing attention, verbal memory, visuospatial ability, and language. CONCLUSION: Our findings indicate that poor executive function especially demanding inhibition and goal-directed behaviors within time limit could be the characteristics of the very early cognitive sign in the course of AD.
BACKGROUND: For the early detection of Alzheimer's disease (AD), there is increasing interest in pre-mild cognitive impairment (pre-MCI). OBJECTIVE: We explored the neuropsychological characteristics in a group of pre-MCI and cognitively normal (CN) elderly individuals, with the aim of providing measures sensitive to cognitive change in pre-MCI. METHODS: We included 188 CN elderly and 77 individuals with pre-MCI. All participants underwent comprehensive clinical and neuropsychological assessment. We compared 17 cognitive tests between the CN and pre-MCI groups by using one-way ANOVAs with false discovery rate correction for multiple comparisons. Pearson's correlations were also obtained between episodic memory and executive function tests in the pre-MCI group. RESULTS: The pre-MCI group showed significantly lower scores for visual immediate recall, fluency tests, and Stroop color naming in the color-word incongruent condition than the CN group (p < 0.05). Most of these executive function measures were significantly correlated with episodic memory (p < 0.05). There were no significant group-differences in other tests assessing attention, verbal memory, visuospatial ability, and language. CONCLUSION: Our findings indicate that poor executive function especially demanding inhibition and goal-directed behaviors within time limit could be the characteristics of the very early cognitive sign in the course of AD.
Entities:
Keywords:
Alzheimer’s disease; early detection; executive function; mild cognitive impairment
Authors: Brett M Frye; Payton M Valure; Suzanne Craft; Mark G Baxter; Christie Scott; Shanna Wise-Walden; David W Bissinger; Hannah M Register; Carson Copeland; Matthew J Jorgensen; Jamie N Justice; Stephen B Kritchevsky; Thomas C Register; Carol A Shively Journal: Geroscience Date: 2021-02-21 Impact factor: 7.713
Authors: Melanie J Koren; Helena M Blumen; Emmeline I Ayers; Joe Verghese; Matthew K Abramowitz Journal: Clin J Am Soc Nephrol Date: 2021-04-06 Impact factor: 8.237
Authors: Hyung Jun Yoon; Seung Gon Kim; Sang Hoon Kim; I L Han Choo; Sang Hag Park; Eun Hyun Seo Journal: Yonsei Med J Date: 2019-10 Impact factor: 2.759
Authors: Laura A Rabin; Crystal G Guayara-Quinn; Caroline O Nester; Liam Ellis; Nadia Paré Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2021-02-23
Authors: Ramón López-Higes; María T Martín-Aragoneses; Susana Rubio-Valdehita; María L Delgado-Losada; Pedro Montejo; Mercedes Montenegro; José M Prados; Jaisalmer de Frutos-Lucas; David López-Sanz Journal: Front Aging Neurosci Date: 2018-02-02 Impact factor: 5.750