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Literature DB >> 27567180

Time To Split Up: Dynamics of Chromosome Separation.

Abstract

The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regulation and has deepened our understanding of how separase activation is coordinated with other events of mitotic exit.

Entities: Gene

Keywords: anaphase; mitosis; mitotic exit; separase

Mesh：

Substances：
Separase

Year: 2016 PMID： 27567180 DOI： 10.1016/j.tcb.2016.07.008

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

11 in total

Review 1. Structural biology of the separase-securin complex with crucial roles in chromosome segregation.

Authors: Shukun Luo; Liang Tong
Journal: Curr Opin Struct Biol Date: 2018-02-14 Impact factor: 6.809

2. Separase-triggered apoptosis enforces minimal length of mitosis.

Authors: Susanne Hellmuth; Olaf Stemmann
Journal: Nature Date: 2020-04-08 Impact factor: 49.962

3. Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

Authors: Andreas Boland; Thomas G Martin; Ziguo Zhang; Jing Yang; Xiao-Chen Bai; Leifu Chang; Sjors H W Scheres; David Barford
Journal: Nat Struct Mol Biol Date: 2017-03-06 Impact factor: 15.369

4. Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase.

Authors: Laurence Cromer; Sylvie Jolivet; Dipesh Kumar Singh; Floriane Berthier; Nancy De Winne; Geert De Jaeger; Shinichiro Komaki; Maria Ada Prusicki; Arp Schnittger; Raphael Guérois; Raphael Mercier
Journal: Proc Natl Acad Sci U S A Date: 2019-07-19 Impact factor: 11.205

5. Transcriptomic Profiling Provides Molecular Insights Into Hydrogen Peroxide-Enhanced Arabidopsis Growth and Its Salt Tolerance.

Authors: Qikun Zhang; Xiuru Dai; Huanpeng Wang; Fanhua Wang; Dongxue Tang; Chunyun Jiang; Xiaoyan Zhang; Wenjing Guo; Yuanyuan Lei; Changle Ma; Hui Zhang; Pinghua Li; Yanxiu Zhao; Zenglan Wang
Journal: Front Plant Sci Date: 2022-04-06 Impact factor: 6.627

6. Identification and Validation of Three Hub Genes Involved in Cell Proliferation and Prognosis of Castration-Resistant Prostate Cancer.

Authors: Pan Yu; Yibei Dai; Tingting Zhuang; Xiaofang Yue; Yuhua Chen; Xuchu Wang; Xiuzhi Duan; Ying Ping; Yiyi Xie; Ying Cao; Zhihua Tao
Journal: Oxid Med Cell Longev Date: 2022-08-17 Impact factor: 7.310

Time To Split Up: Dynamics of Chromosome Separation.

Review 1. Structural biology of the separase-securin complex with crucial roles in chromosome segregation.

2. Separase-triggered apoptosis enforces minimal length of mitosis.

3. Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

4. Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase.

5. Transcriptomic Profiling Provides Molecular Insights Into Hydrogen Peroxide-Enhanced Arabidopsis Growth and Its Salt Tolerance.

6. Identification and Validation of Three Hub Genes Involved in Cell Proliferation and Prognosis of Castration-Resistant Prostate Cancer.

7. Structural basis of human separase regulation by securin and CDK1-cyclin B1.

8. Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition.

9. Separase is a marker for prognosis and mitotic activity in breast cancer.

10. A prognostic model based on cell-cycle control predicts outcome of breast cancer patients.