Jameela PonMalar1, Santosh Joseph Benjamin1, Anuja Abraham1, Swati Rathore1, Visalakshi Jeyaseelan2, Jiji Elizabeth Mathews3. 1. Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India. 2. Department of Biostatistics, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India. 3. Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India. coronistrial@yahoo.co.in.
Abstract
OBJECTIVE: To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 381/2 and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4. METHOD:Sixty three women received 25 μgvaginal misoprostol and 63 women received placebo after stretch and sweep. RESULTS: The duration from intervention to delivery was 3.35 (1.12-9.46) days in the misoprostol group and 5.42 (2.39-10.11) days in the placebo group which was statistically significant (p = 0.029). Spontaneous labor was seen in 39 women (61.9 %) in the misoprostol group and 35 women (55.6 %) in the placebo group (p = 0.531). Eight women in the misoprostol group and 18 in the placebo group had Lower Segment Caesarean Section (LSCS) and this difference was also statistically significant (p = 0.027). There were no major maternal and neonatal complications in both groups. CONCLUSION: Preinduction use of 25 μg vaginal misoprostol after stretch and sweep in the outpatient setting decreased the intervention to delivery interval when compared to placebo.
RCT Entities:
OBJECTIVE: To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 381/2 and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4. METHOD: Sixty three women received 25 μg vaginal misoprostol and 63 women received placebo after stretch and sweep. RESULTS: The duration from intervention to delivery was 3.35 (1.12-9.46) days in the misoprostol group and 5.42 (2.39-10.11) days in the placebo group which was statistically significant (p = 0.029). Spontaneous labor was seen in 39 women (61.9 %) in the misoprostol group and 35 women (55.6 %) in the placebo group (p = 0.531). Eight women in the misoprostol group and 18 in the placebo group had Lower Segment Caesarean Section (LSCS) and this difference was also statistically significant (p = 0.027). There were no major maternal and neonatal complications in both groups. CONCLUSION: Preinduction use of 25 μg vaginal misoprostol after stretch and sweep in the outpatient setting decreased the intervention to delivery interval when compared to placebo.