Literature DB >> 27566144

Review of Advances in Uroprotective Agents for Cyclophosphamide- and Ifosfamide-induced Hemorrhagic Cystitis.

Ethan L Matz1, Michael H Hsieh2.   

Abstract

Cyclophosphamide and ifosfamide are widely used drugs for malignancies and rheumatologic conditions. One of the most significant adverse reactions to these drugs is hemorrhagic cystitis. Mesna is the most widely used uroprotective agent that acts to neutralize the caustic metabolite, acrolein, responsible for induction of hemorrhagic cystitis. However, mesna is not a perfect alternative, and studies since its discovery have investigated the use of alternative drugs and adjuncts to increase mesna's efficacy. This review details some of the recent work into novel uroprotective agents for drug-induced hemorrhagic cystitis.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27566144     DOI： 10.1016/j.urology.2016.07.030

Source DB:  PubMed          Journal:  Urology        ISSN： 0090-4295            Impact factor:   2.649


  26 in total

Review 1.  Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.

Authors:  Bernadette M M Zwaans; Laura E Lamb; Sarah Bartolone; Heinz E Nicolai; Michael B Chancellor; Stangel-Wójcikiewicz Klaudia
Journal:  Int Urol Nephrol       Date:  2018-08-21       Impact factor: 2.370

Review 2.  The Urothelium: Life in a Liquid Environment.

Authors:  Marianela G Dalghi; Nicolas Montalbetti; Marcelo D Carattino; Gerard Apodaca
Journal:  Physiol Rev       Date:  2020-03-19       Impact factor: 37.312

3.  IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.

Authors:  Rebecca S Zee; Evaristus C Mbanefo; Loc H Le; Luke F Pennington; Justin I Odegaard; Theodore S Jardetzky; Abdulaziz Alouffi; Jude Akinwale; Franco H Falcone; Michael H Hsieh
Journal:  Am J Physiol Renal Physiol       Date:  2019-02-20

4.  Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction.

Authors:  Nao Iguchi; M İrfan Dönmez; Alonso Carrasco; Duncan T Wilcox; Ricardo H Pineda; Anna P Malykhina; Nicholas G Cost
Journal:  Am J Physiol Renal Physiol       Date:  2019-05-08

5.  Acid-sensing ion channels modulate bladder nociception.

Authors:  Nicolas Montalbetti; Marcelo D Carattino
Journal:  Am J Physiol Renal Physiol       Date:  2021-09-13

6.  Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide.

Authors:  Petr Jost; Jaroslav Pejchal; Tomas Kucera; Lubica Muckova; Rudolf Stetina
Journal:  J Appl Biomed       Date:  2019-06-17       Impact factor: 1.797

7.  Durability of and role of AKT in FGF7p urothelial protection against cyclophosphamide.

Authors:  Sridhar Tatarao Narla; Lori Rice; David Ostrov; Daniel Scott Bushnell; Joanne Lindsey Duara; Carlton Matthew Bates
Journal:  Physiol Rep       Date:  2022-06

8.  The Effect of Acetylcysteine on Renal Function in Experimental Models of Cyclophosphamide-and Ifosfamide-Induced Cystitis.

Authors:  Lukasz Dobrek; Klaudia Nalik-Iwaniak; Kinga Fic; Zbigniew Arent
Journal:  Curr Urol       Date:  2020-10-13

9.  AKT Signaling Downstream of KGF Is Necessary and Sufficient for Blocking Cyclophosphamide Bladder Injury.

Authors:  Sridhar T Narla; Daniel S Bushnell; Joanne L Duara; Carlton M Bates
Journal:  Am J Pathol       Date:  2022-01-19       Impact factor: 5.770

10.  Loss of Fibroblast Growth Factor Receptor 2 (FGFR2) Leads to Defective Bladder Urothelial Regeneration after Cyclophosphamide Injury.

Authors:  Sridhar T Narla; Daniel S Bushnell; Caitlin M Schaefer; Mehdi Nouraie; Justin T Tometich; Timothy W Hand; Carlton M Bates
Journal:  Am J Pathol       Date:  2020-12-30       Impact factor: 5.770
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