Johannes Budjan1, Urs Benck2, Alexander Lammert2, Melissa M Ong3, Miryana Mircheva2, Steffen Diehl3, Simon Konstandin4, Lothar R Schad5, Bernhard K Krämer2, Stefan O Schoenberg3, Stefan Haneder6. 1. Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany johannes.budjan@umm.de. 2. Fifth Department of Internal Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 3. Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 4. Computer Assisted Clinical Medicine, University Medical Center Mannheim, Mannheim, Germany MR-Imaging and Spectroscopy, Faculty 01 (Physics/Electrical Engineering), University of Bremen, Bremen, Germany. 5. Computer Assisted Clinical Medicine, University Medical Center Mannheim, Mannheim, Germany. 6. Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Department of Radiology, University Hospital of Cologne, Cologne, Germany.
Abstract
BACKGROUND/AIM: Renal denervation (RDN) has been considered a promising therapy option for patients suffering from therapy-resistant hypertension. Besides, in blood-pressure regularization, the kidneys play a fundamental role in sodium ((23)Na) homeostasis. This study assesses the effect of RDN on renal (23)Na concentration using (23)Na magnetic resonance imaging (MRI). PATIENTS AND METHODS: Two patients with therapy-resistant hypertension underwent RDN. (23)Na-MRI, (1)H-MRI, including diffusion weighted imaging (DWI), as well as endothelial dysfunction assessment, were performed 1 day prior, as well as 1, 30 and 90 days after RDN. RESULTS: The renal corticomedullary (23)Na gradient did not change after RDN for all time points. Additionally, functional imaging and retinal vessel parameters were not influenced by RDN. Results regarding blood pressure changes and arterial stiffness, as well as patients' clinical outcome, were heterogeneous. CONCLUSION: RDN does not seem to alter renal (23)Na concentration gradients, as measured by MRI.
BACKGROUND/AIM: Renal denervation (RDN) has been considered a promising therapy option for patients suffering from therapy-resistant hypertension. Besides, in blood-pressure regularization, the kidneys play a fundamental role in sodium ((23)Na) homeostasis. This study assesses the effect of RDN on renal (23)Na concentration using (23)Na magnetic resonance imaging (MRI). PATIENTS AND METHODS: Two patients with therapy-resistant hypertension underwent RDN. (23)Na-MRI, (1)H-MRI, including diffusion weighted imaging (DWI), as well as endothelial dysfunction assessment, were performed 1 day prior, as well as 1, 30 and 90 days after RDN. RESULTS: The renal corticomedullary (23)Na gradient did not change after RDN for all time points. Additionally, functional imaging and retinal vessel parameters were not influenced by RDN. Results regarding blood pressure changes and arterial stiffness, as well as patients' clinical outcome, were heterogeneous. CONCLUSION: RDN does not seem to alter renal (23)Na concentration gradients, as measured by MRI.
Authors: Iosif Mendichovszky; Pim Pullens; Ilona Dekkers; Fabio Nery; Octavia Bane; Andreas Pohlmann; Anneloes de Boer; Alexandra Ljimani; Aghogho Odudu; Charlotte Buchanan; Kanishka Sharma; Christoffer Laustsen; Anita Harteveld; Xavier Golay; Ivan Pedrosa; David Alsop; Sean Fain; Anna Caroli; Pottumarthi Prasad; Susan Francis; Eric Sigmund; Maria Fernández-Seara; Steven Sourbron Journal: MAGMA Date: 2019-10-18 Impact factor: 2.310