Literature DB >> 27565339

Getting IN on Viral RNA Condensation and Virion Maturation.

Eric O Freed1.   

Abstract

The retroviral enzyme integrase plays an essential role in the virus replication cycle by catalyzing the covalent insertion of newly synthesized viral DNA into the host cell chromosome early after infection. Now, Kessl et al. report a second function of integrase: binding to the viral RNA genome in virion particles late in the virus replication cycle to promote particle maturation. Published by Elsevier Inc.

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Year:  2016        PMID： 27565339      PMCID： PMC6941196          DOI： 10.1016/j.cell.2016.08.013

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

Review 1.  In vivo analysis of retroviral integrase structure and function.

Authors:  A Engelman
Journal:  Adv Virus Res       Date:  1999       Impact factor: 9.937

2.  Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation.

Authors:  Juan Fontana; Kellie A Jurado; Naiqian Cheng; Ngoc L Ly; James R Fuchs; Robert J Gorelick; Alan N Engelman; Alasdair C Steven
Journal:  J Virol       Date:  2015-07-15       Impact factor: 5.103

3.  Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase.

Authors:  A B Hickman; I Palmer; A Engelman; R Craigie; P Wingfield
Journal:  J Biol Chem       Date:  1994-11-18       Impact factor: 5.157

Review 4.  HIV-1 assembly, release and maturation.

Authors:  Eric O Freed
Journal:  Nat Rev Microbiol       Date:  2015-06-29       Impact factor: 60.633

5.  HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.

Authors:  Jacques J Kessl; Sebla B Kutluay; Dana Townsend; Stephanie Rebensburg; Alison Slaughter; Ross C Larue; Nikoloz Shkriabai; Nordine Bakouche; James R Fuchs; Paul D Bieniasz; Mamuka Kvaratskhelia
Journal:  Cell       Date:  2016-08-25       Impact factor: 41.582

6.  Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.

Authors:  Kellie A Jurado; Hao Wang; Alison Slaughter; Lei Feng; Jacques J Kessl; Yasuhiro Koh; Weifeng Wang; Allison Ballandras-Colas; Pratiq A Patel; James R Fuchs; Mamuka Kvaratskhelia; Alan Engelman
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-22       Impact factor: 11.205

Review 7.  Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.

Authors:  Kellie Ann Jurado; Alan Engelman
Journal:  Expert Rev Mol Med       Date:  2013-11-26       Impact factor: 5.600

8.  LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.

Authors:  Belete Ayele Desimmie; Rik Schrijvers; Jonas Demeulemeester; Doortje Borrenberghs; Caroline Weydert; Wannes Thys; Sofie Vets; Barbara Van Remoortel; Johan Hofkens; Jan De Rijck; Jelle Hendrix; Norbert Bannert; Rik Gijsbers; Frauke Christ; Zeger Debyser
Journal:  Retrovirology       Date:  2013-05-30       Impact factor: 4.602

9.  HITS-CLIP yields genome-wide insights into brain alternative RNA processing.

Authors:  Donny D Licatalosi; Aldo Mele; John J Fak; Jernej Ule; Melis Kayikci; Sung Wook Chi; Tyson A Clark; Anthony C Schweitzer; John E Blume; Xuning Wang; Jennifer C Darnell; Robert B Darnell
Journal:  Nature       Date:  2008-11-02       Impact factor: 49.962
  9 in total
  1 in total

1.  Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA.

Authors:  Shelby Winans; Stephen P Goff
Journal:  PLoS Pathog       Date:  2020-12-22       Impact factor: 6.823
  1 in total

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