| Literature DB >> 27565338 |
Gary Kleiger1, Raymond Deshaies2.
Abstract
Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.Entities:
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Year: 2016 PMID： 27565338 DOI： 10.1016/j.cell.2016.08.014
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582